Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase - Wikidata - awgldk - TriplyDB

Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase

Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase

http://www.wikidata.org/entity/Q24671402

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Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2 Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4 Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species Allosteric coupling in pyruvate dehydrogenase kinase 2 The pyruvate dehydrogenase complexes: structure-based function and regulation.Regulation of pyruvate metabolism and human disease Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders.Histidine kinases from bacteria to humans.The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.Detection of pyruvate dehydrogenase E1 alpha-subunit deficiencies in females by immunohistochemical demonstration of mosaicism in cultured fibroblasts.Role of protein-protein interactions in the regulation of pyruvate dehydrogenase kinase activity.The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activity.Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.Histidine mutagenesis of Arabidopsis thaliana pyruvate dehydrogenase kinase.R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.Comparative homology modeling of pyruvate dehydrogenase kinase isozymes from Xenopus tropicalis reveals structural basis for their subfunctionalization.Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.

P2860

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P2860

Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase

http://www.wikidata.org/entity/Q24671402

description

2001 nî lūn-bûn

@nan

2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Structure of pyruvate dehydrog ...... rn for a serine protein kinase

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Journal of Biological Chemistry

P1476

Structure of pyruvate dehydrog ...... rn for a serine protein kinase

@en

P2093

C N Steussy

http://www.w3.org/2001/XMLSchema#string

J A Hamilton

http://www.w3.org/2001/XMLSchema#string

K M Popov

http://www.w3.org/2001/XMLSchema#string

M M Bowker-Kinley

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R A Harris

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R B Sloan

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P2860

Marked differences between two isoforms of human pyruvate dehydrogenase kinase

The Protein Data Bank

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

Nucleotide binding by the histidine kinase CheA

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

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37443-50

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scholarly article

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10.1074/JBC.M104285200

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40

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P478

276

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2001-10-05T00:00:00Z

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11483605

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protein structure

protein folding

P932

2147663

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