Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling.
about
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RSVPAC receptors: structure, molecular pharmacology and interaction with accessory proteinsTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsActivation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probesThe vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamicsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity.Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis.Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin ReceptorReceptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity.Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.The VPAC1 receptor: structure and function of a class B GPCR prototype.Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptorsExploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptidesStructural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.Structural aspects of gut peptides with therapeutic potential for type 2 diabetes.Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor.Chemical synthesis and characterization of silver-protected vasoactive intestinal peptide nanoparticles.Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.
P2860
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P2860
Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
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2006年學術文章
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name
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@en
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@nl
type
label
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@en
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@nl
prefLabel
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@en
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@nl
P2093
P2860
P356
P1476
Peptide agonist docking in the ...... , NMR, and molecular modeling.
@en
P2093
Alain Couvineau
Emilie Ceraudo
Jean-Jacques Lacapère
Jean-Michel Neumann
Marc Laburthe
Samuel Murail
Yossan-Var Tan
P2860
P304
12792-12798
P356
10.1074/JBC.M513305200
P407
P577
2006-03-06T00:00:00Z