Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment.
about
Interleukin-2 receptor signaling: at the interface between tolerance and immunityDiacylglycerol Kinases in T Cell Tolerance and Effector FunctionConcurrent generation of effector and central memory CD8 T cells during vaccinia virus infection.Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice.IL-7 + IL-15 are superior to IL-2 for the ex vivo expansion of 4T1 mammary carcinoma-specific T cells with greater efficacy against tumors in vivo.Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells.Inflammatory cytokines as a third signal for T cell activationMemory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells.T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum.Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cellsA critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells.The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development.Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells.Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates.Not-so-great expectations: re-assessing the essence of T-cell memory.CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs.IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopeniaThe Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation.Programming for CD8 T cell memory development requires IL-12 or type I IFNCD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.Interleukin 7 receptor alpha as a potential therapeutic target in transplantation.Opposing functions of IL-2 and IL-7 in the regulation of immune responses.CD8(+) T cells: foot soldiers of the immune systemThe role of donor-derived veto cells in nonmyeloablative haploidentical HSCT.Expression of bovine interleukin 15 and evaluation of its biological activity in vitro.Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.Efficacy of IL-2- versus IL-15-stimulated CD8 T cells in adoptive immunotherapy.Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.Profiling of Protein O-GlcNAcylation in Murine CD8+ Effector- and Memory-like T Cells.A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells.Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.Downregulation of interleukin-7 and hepatocyte growth factor in the thymic microenvironment is associated with thymus involution in tumor-bearing mice.Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen.Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells.Short-term stress experienced at time of immunization induces a long-lasting increase in immunologic memory.
P2860
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P2860
Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Initial antigen encounter prog ...... 7- and IL-15-rich environment.
@en
Initial antigen encounter prog ...... 7- and IL-15-rich environment.
@nl
type
label
Initial antigen encounter prog ...... 7- and IL-15-rich environment.
@en
Initial antigen encounter prog ...... 7- and IL-15-rich environment.
@nl
prefLabel
Initial antigen encounter prog ...... 7- and IL-15-rich environment.
@en
Initial antigen encounter prog ...... 7- and IL-15-rich environment.
@nl
P1476
Initial antigen encounter prog ...... -7- and IL-15-rich environment
@en
P2093
Oliver F Bathe
Thomas R Malek
P304
P356
10.4049/JIMMUNOL.172.12.7315
P407
P50
P577
2004-06-01T00:00:00Z