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Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomasSevere combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damageK27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomasDissecting the genomic complexity underlying medulloblastomaEpigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumorsGenome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibitionImmune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.Subgroup-specific structural variation across 1,000 medulloblastoma genomesAttitudes of Canadian researchers toward the return to participants of incidental and targeted genomic findings obtained in a pediatric research settingX-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) geneGene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma.Pediatric high-grade glioma: biologically and clinically in need of new thinkingIntegrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid TumorsUnexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing.Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomasGenome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability.Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomasMYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.Extracellular vesicles as prospective carriers of oncogenic protein signatures in adult and paediatric brain tumours.Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastomaIron chelators modulate the fusogenic properties of Salmonella-containing phagosomesAn inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly.Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin.Clonal selection drives genetic divergence of metastatic medulloblastoma.Promoting an ethic of engagement in pediatric palliative care research.Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct.Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease.A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method.Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomasA recurrent PDGFRB mutation causes familial infantile myofibromatosis.
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