Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.
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Androgen-modulating agents for spinal bulbar muscular atrophy/Kennedy's diseasePathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in modelCell biology of spinocerebellar ataxiaMouse models of polyglutamine diseases: review and data table. Part ISumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesisMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophyDeveloping treatment for spinal and bulbar muscular atrophyThe unstable repeats--three evolving faces of neurological diseaseDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseOpposing effects of polyglutamine expansion on native protein complexes contribute to SCA1Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapyPreventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMASmall ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregationGcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant proteinOverexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophyAndrogen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy.Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patientsTherapeutic approaches to spinal and bulbar muscular atrophyThe 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct MechanismsAntiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.Correlation of clinical and molecular features in spinal bulbar muscular atrophy.Animal models of Kennedy disease.Androgen receptor and Kennedy disease/spinal bulbar muscular atrophyMacroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice.An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophiesRecovery of function in a myogenic mouse model of spinal bulbar muscular atrophy.Risk factors for metastatic castration-resistant prostate cancer (CRPC) predict long-term treatment with docetaxelSpinal and Bulbar Muscular Atrophy.Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophyEfficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial.Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.
P2860
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P2860
Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
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name
Castration restores function a ...... l and bulbar muscular atrophy.
@en
Castration restores function a ...... l and bulbar muscular atrophy.
@nl
type
label
Castration restores function a ...... l and bulbar muscular atrophy.
@en
Castration restores function a ...... l and bulbar muscular atrophy.
@nl
prefLabel
Castration restores function a ...... l and bulbar muscular atrophy.
@en
Castration restores function a ...... l and bulbar muscular atrophy.
@nl
P2093
P1476
Castration restores function a ...... al and bulbar muscular atrophy
@en
P2093
Andrew P Lieberman
Christopher J O'Brien
Diane E Merry
Erica S Chevalier-Larsen
Huiyi Wang
Latia Holder
Shannon C Jenkins
P304
P356
10.1523/JNEUROSCI.0808-04.2004
P407
P577
2004-05-01T00:00:00Z