Donor CD8+ T cells mediate graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with anti-CD3 monoclonal antibody.
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Depletion of host CCR7(+) dendritic cells prevented donor T cell tissue tropism in anti-CD3-conditioned recipients.Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effectsInduction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes.Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD miceB7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host diseaseElimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD miceLack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cellsHDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen.Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease.Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI.Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.Intratumoral interferon-alpha gene transfer enhances tumor immunity after allogeneic hematopoietic stem cell transplantation.Combination of intra-bone marrow-bone marrow transplantation and subcutaneous donor splenocyte injection diminishes risk of graft-versus-host disease and enhances survival rate.PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells.
P2860
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P2860
Donor CD8+ T cells mediate graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with anti-CD3 monoclonal antibody.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@en
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@nl
type
label
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@en
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@nl
prefLabel
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@en
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@nl
P2093
P1476
Donor CD8+ T cells mediate gra ...... anti-CD3 monoclonal antibody.
@en
P2093
Chunyan Zhang
Fouad Kandeel
Ivan Todorov
Jingwei Lou
Nainong Li
Stephen Forman
P304
P356
10.4049/JIMMUNOL.178.2.838
P407
P577
2007-01-01T00:00:00Z