Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening.
about
Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosisTAO kinases mediate activation of p38 in response to DNA damageA small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinaseImproved targeting of miRNA with antisense oligonucleotidesFrom ORFeome to biology: a functional genomics pipelineA gene atlas of the mouse and human protein-encoding transcriptomesHuman host factors required for influenza virus replicationSmall silencing RNAs: an expanding universeA genome-wide RNAi screen for modifiers of the circadian clock in human cellsSynthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancerCD155/PVR plays a key role in cell motility during tumor cell invasion and migrationDecoding the riddle: the dawn of RNAi for the study of gene-gene and gene-environment interactionssiRNA-mediated off-target gene silencing triggered by a 7 nt complementationFunctional polarity is introduced by Dicer processing of short substrate RNAs.Thorough validation of siRNA-induced cell death phenotypes defines new anti-apoptotic proteinAdvances in targeted and immunobased therapies for colorectal cancer in the genomic eraMitochondrial targets for pharmacological intervention in human diseaseSynthetic lethality in lung cancer and translation to clinical therapiesIntegrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapyFunctional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasivenessIntegrated functional, gene expression and genomic analysis for the identification of cancer targetsCell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock modelsA genome-wide over-expression screen identifies genes involved in phagocytosis in the human protozoan parasite, Entamoeba histolytica.Data Analysis for High-Throughput RNAi Screening.Genome-wide screening for gene function using RNAi in mammalian cells.An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.Silence of the genes.Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particleComplete, gene-specific siRNA libraries: production and expression in mammalian cells.Gene discovery by ribozyme and siRNA libraries.Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis.How will RNAi facilitate drug development?Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.Genome-wide application of RNAi to the discovery of potential drug targets.A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infectionSpecific and nontoxic silencing in mammalian cells with expressed long dsRNAs.Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.Genome-wide functional analysis of human cell-cycle regulators.High-throughput screening using siRNA (RNAi) libraries.
P2860
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P2860
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Identification of modulators o ...... Ai-based phenotypic screening.
@en
Identification of modulators o ...... Ai-based phenotypic screening.
@nl
type
label
Identification of modulators o ...... Ai-based phenotypic screening.
@en
Identification of modulators o ...... Ai-based phenotypic screening.
@nl
prefLabel
Identification of modulators o ...... Ai-based phenotypic screening.
@en
Identification of modulators o ...... Ai-based phenotypic screening.
@nl
P2093
P1433
P1476
Identification of modulators o ...... Ai-based phenotypic screening.
@en
P2093
Christopher L Cooper
Klaus Wagner
Michael P Cooke
Pedro Aza-Blanc
Quinn L Deveraux
Serge Batalov
P304
P356
10.1016/S1097-2765(03)00348-4
P577
2003-09-01T00:00:00Z