Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.

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Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

@yue

2017年學術文章

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name

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@en

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@nl

type

Item

label

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@en

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@nl

prefLabel

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@en

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@nl

P1476

Discovery of a novel 2,4-dimet ...... hemotype via scaffold hopping.

@en

P2093

Alice L Rodriguez

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Darren W Engers

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Hyekyung P Cho

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Julie L Engers

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Madeline F Long

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Rebecca L Weiner

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Sichen Chang

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Thomas M Bridges

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Vincent B Luscombe

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Xiaoyan Zhan

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P2860

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.

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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.

The antipsychotic potential of muscarinic allosteric modulation

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia

P304

4999-5001

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P31

scholarly article

P356

10.1016/J.BMCL.2017.10.016

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

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P50

Colleen M. Niswender

Craig W. Lindsley

P Jeffrey Conn

P577

2017-10-09T00:00:00Z

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P698

29037946

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P932

5784840

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