Immunochemistry of sperm whale myoglobin. I. The specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen.
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Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesisAntibodies to a unique region in lysozyme provoked by a synthetic antigen conjugate.T cell clones reactive with sperm whale myoglobin. Isolation of clones with specificity for individual determinants on myoglobin.Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme.Antibodies against a synthetic peptide of the poliovirus replicase protein: reaction with native, virus-encoded proteins and inhibition of virus-specific polymerase activities in vitroEpitope-specific suppression of antibody response in experimental autoimmune myasthenia gravis by a monomethoxypolyethylene glycol conjugate of a myasthenogenic synthetic peptide.Antibodies reactive with native lysozyme elicited by a completely synthetic antigen.Sequence differences of Escherichia coli 30S ribosomal proteins as determined by immunochemical methods.An immunologic approach to the conformational equilibria of polypeptides.Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin.Determination of the entire antigenic structure of native lysozyme by surface-simulation synthesis, a novel concept in molecular recognition.Insights into the active site of the cytochrome P-450 haemoprotein family--a unifying concept based on structural considerations.Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603Surface-simulation synthesis of the substrate-binding site of an enzyme. Demonstration with trypsinA novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin.Immunologically reactive tryptic fragments of human prostatic acid phosphataseCleavage of bacterial flagellin with cyanogen bromide. Chemical and physical properties of the protein fragments.Non-specific peptide size effects in the recognition by site-specific T-cell clones. Demonstration with a T site of myoglobin.The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raiseThe precise and entire antigenic structure of native lysozyme.Site recognition by protein-primed T cells shows a non-specific peptide size requirement beyond the essential residues of the site. Demonstration by defining an immunodominant T site in myoglobin.Localization and verification by synthesis of five antigenic sites of bovine serum albumin.Delineation of the third antigenic site of lysozyme by application of a novel 'surface-simulation' synthetic approach directly linking the conformationally adjacent residues forming the site.Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.Antigenic structure of human haemoglobin. Localization of the antigenic sites of the beta-chain in three host species by synthetic overlapping peptides representing the entire chainStructurally inherent antigenic sites. Localization of the antigenic sites of the alpha-chain of human haemoglobin in three host species by a comprehensive synthetic approach.Immunochemical studies on human calcitonin M leading to information on the shape of the molecule.Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.
P2860
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P2860
Immunochemistry of sperm whale myoglobin. I. The specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen.
description
1968 nî lūn-bûn
@nan
1968年の論文
@ja
1968年学术文章
@wuu
1968年学术文章
@zh
1968年学术文章
@zh-cn
1968年学术文章
@zh-hans
1968年学术文章
@zh-my
1968年学术文章
@zh-sg
1968年學術文章
@yue
1968年學術文章
@zh-hant
name
Immunochemistry of sperm whale ...... active regions of the antigen.
@en
Immunochemistry of sperm whale ...... active regions of the antigen.
@nl
type
label
Immunochemistry of sperm whale ...... active regions of the antigen.
@en
Immunochemistry of sperm whale ...... active regions of the antigen.
@nl
prefLabel
Immunochemistry of sperm whale ...... active regions of the antigen.
@en
Immunochemistry of sperm whale ...... active regions of the antigen.
@nl
P356
P1433
P1476
Immunochemistry of sperm whale ...... active regions of the antigen.
@en
P2093
P304
P356
10.1021/BI00842A026
P407
P577
1968-02-01T00:00:00Z