Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.
about
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeletonErk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASPA Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxisPhosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome proteinLoss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cellsThe Wiskott-Aldrich syndromeGTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivoGenetically engineered mouse models for studying inflammatory bowel diseaseHuman Immunodeficiencies Related to Defective APC/T Cell InteractionWIP remodeling actin behind the scenes: how WIP reshapes immune and other functionsActin cytoskeletal defects in immunodeficiencyMolecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.The chemotactic defect in wiskott-Aldrich syndrome macrophages is due to the reduced persistence of directional protrusionsImpaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosisWiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cellsWiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and functionPhosphorylation site dynamics of early T-cell receptor signalingADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugationSkap2 is required for β2 integrin-mediated neutrophil recruitment and functions.Single domain intrabodies against WASP inhibit TCR-induced immune responses in transgenic mice T cells.The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton.FOXP3+ Tregs require WASP to restrain Th2-mediated food allergyCdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.Specific patterns of Cdc42 activity are related to distinct elements of T cell polarizationA balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling.Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamicsCdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubulesA numerical analysis model for the interpretation of in vivo platelet consumption data.Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation.Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamicsA DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.Actin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityIn Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells.Retrovirus-mediated WASP gene transfer corrects defective actin polymerization in B cell lines from Wiskott-Aldrich syndrome patients carrying 'null' mutations.Monocytes from Wiskott-Aldrich patients differentiate in functional mature dendritic cells with a defect in CD83 expression.WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.
P2860
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P2860
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@en
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@nl
type
label
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@en
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@nl
prefLabel
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@en
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@nl
P2093
P1433
P1476
Wiskott-Aldrich syndrome prote ...... n T but not B cell activation.
@en
P2093
Davidson L
Hagemann TL
Mizoguchi E
P356
10.1016/S1074-7613(00)80590-7
P407
P577
1998-07-01T00:00:00Z