Aggrecan protects cartilage collagen from proteolytic cleavage. - Wikidata - awgldk - TriplyDB

Aggrecan protects cartilage collagen from proteolytic cleavage.

Aggrecan protects cartilage collagen from proteolytic cleavage.

http://www.wikidata.org/entity/Q47724408

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ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors The ADAMTS metalloproteinases Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.Cartilage aggrecan can undergo self-adhesion.In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.Cell-penetrating peptides released from thermosensitive nanoparticles suppress pro-inflammatory cytokine response by specifically targeting inflamed cartilage explants.Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage.Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis.Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications.Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis.Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031.Proteases involved in cartilage matrix degradation in osteoarthritis.Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants.Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6.Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage Biomimetic molecules lower catabolic expression and prevent chondroitin sulfate degradation in an osteoarthritic ex vivo model Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.Metalloproteases as potential therapeutic targets in arthritis treatment.Dexamethasone promotes calcium pyrophosphate dihydrate crystal formation by articular chondrocytes.Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro Composition-function relationships during IL-1-induced cartilage degradation and recovery.CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model.microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1β-induced Osteoarthritis.Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.Soft texture of atlantic salmon fillets is associated with glycogen accumulation.

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P2860

Aggrecan protects cartilage collagen from proteolytic cleavage.

http://www.wikidata.org/entity/Q47724408

description

2003 nî lūn-bûn

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2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Aggrecan protects cartilage collagen from proteolytic cleavage.

@en

Aggrecan protects cartilage collagen from proteolytic cleavage.

@nl

type

label

Aggrecan protects cartilage collagen from proteolytic cleavage.

@en

Aggrecan protects cartilage collagen from proteolytic cleavage.

@nl

prefLabel

Aggrecan protects cartilage collagen from proteolytic cleavage.

@en

Aggrecan protects cartilage collagen from proteolytic cleavage.

@nl

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P1433

Journal of Biological Chemistry

P1476

Aggrecan protects cartilage collagen from proteolytic cleavage.

@en

P2093

Carl Decicco

http://www.w3.org/2001/XMLSchema#string

Elizabeth C Arner

http://www.w3.org/2001/XMLSchema#string

James M Trzaskos

http://www.w3.org/2001/XMLSchema#string

Michael A Pratta

http://www.w3.org/2001/XMLSchema#string

Micky D Tortorella

http://www.w3.org/2001/XMLSchema#string

Riu-Qin Liu

http://www.w3.org/2001/XMLSchema#string

Robert A Copeland

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Robert C Newton

http://www.w3.org/2001/XMLSchema#string

Ronald Magolda

http://www.w3.org/2001/XMLSchema#string

Wenqing Yao

http://www.w3.org/2001/XMLSchema#string

P2860

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage

Decorin interacts with fibrillar collagen of embryonic and adult human skin

Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.

Balance between swelling pressure and collagen tension in normal and degenerate cartilage.

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration

Proteoglycan: collagen interactions in connective tissues. Ultrastructural, biochemical, functional and evolutionary aspects.

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

P304

45539-45545

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scholarly article

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10.1074/JBC.M303737200

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P407

P433

46

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P478

278

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2003-07-30T00:00:00Z

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12890681

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