Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
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Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseIndoctrinating T cells to attack pathogens through homeschoolingSulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognitionStructural Model of the Extracellular Assembly of the TCR-CD3 Complex.A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signalingHard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptabilityAllelic polymorphism in the T cell receptor and its impact on immune responsesRigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor TriggeringT Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational RearrangementsThe Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I MoleculeStructure of the Chicken CD3 / Heterodimer and Its Assembly with the T Cell ReceptorEvidence for a functional sidedness to the alphabetaTCR.DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.T cell receptor triggering by force.An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Organization of proximal signal initiation at the TCR:CD3 complex.Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.Constitutively active Lck kinase in T cells drives antigen receptor signal transductionPiecing together the family portrait of TCR-CD3 complexes.Molecular architecture of the αβ T cell receptor-CD3 complex.Early relaxation dynamics in the LC 13 T cell receptor in reaction to 172 altered peptide ligands: a molecular dynamics simulation studyOn the logic of restrictive recognition of peptide by the T-cell antigen receptor.Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope RecognitionHeterogeneity within T Cell Memory: Implications for Transplant ToleranceInterplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations.Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity.A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.Pre-clustered TCR complexes.Inside the microcluster: antigen receptor signalling viewed with molecular imaging tools.TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.Current status and future challenges in T-cell receptor/peptide/MHC molecular dynamics simulations.Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors
P2860
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P2860
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
@zh-hant
name
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@en
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@nl
type
label
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@en
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@nl
prefLabel
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@en
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@nl
P2093
P50
P1433
P1476
Antigen ligation triggers a co ...... the alphabeta T cell receptor.
@en
P2093
Craig S Clements
Lars Kjer-Nielsen
Lauren K Ely
Matthew C J Wilce
Siew Siew Pang
Stephen P Bottomley
Whitney A Macdonald
Yu Chih Liu
Zhenjun Chen
P304
P356
10.1016/J.IMMUNI.2009.03.018
P407
P50
P577
2009-05-21T00:00:00Z