Analysis of a core domain in Drosophila DNA topoisomerase II. Targeting of an antitumor agent ICRF-159.
about
Characterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase IIStructure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.Hepatitis C virus biology.Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalphaDNA topoisomerases: harnessing and constraining energy to govern chromosome topology.A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.A human topoisomerase II alpha heterodimer with only one ATP binding site can go through successive catalytic cycles.Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide.ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization.Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.Topoisomerases as anticancer targets.
P2860
Q24793787-1158679A-9E95-4027-A987-9DE51AFAFAC3Q27641998-AE4B0F85-1CA3-43E6-92BA-10E19AB5C5A7Q30661486-B1CAA464-83D0-43CB-8048-048A8B3A295CQ35091465-DEB70A62-6536-4499-82CA-0AF4191D7CE0Q36118901-B797FBF8-9048-478C-8221-374EC9820DBCQ37255381-6D47D59C-E93A-477D-87CB-9012BEB58C99Q38343316-1E7F1A13-E734-4555-A0DC-057AF1D35180Q38359821-AA11BC61-8658-4F95-AA00-B1FAC2389955Q42953188-B147A900-A44E-4DE3-B230-45E8CD41602FQ43890632-7F9CD57E-B43F-4AB1-AF8A-DFD487449CBCQ44014803-43446ECC-2796-4ED2-ABEF-90BAA2C3A059Q49832269-D81A7F8C-7BE9-4918-8546-96BD654211CF
P2860
Analysis of a core domain in Drosophila DNA topoisomerase II. Targeting of an antitumor agent ICRF-159.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@en
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@nl
type
label
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@en
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@nl
prefLabel
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@en
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@nl
P2093
P2860
P356
P1476
Analysis of a core domain in D ...... f an antitumor agent ICRF-159.
@en
P2093
P2860
P304
19822-19828
P356
10.1074/JBC.273.31.19822
P407
P577
1998-07-01T00:00:00Z