DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
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A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and EucaryaBiochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesDNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNAIncorporation of omics analyses into artificial gravity research for space exploration countermeasure developmentDNA topology and transcriptionDNA triplet repeat expansion and mismatch repairDrugging topoisomerases: lessons and challengesDirect observation of strand passage by DNA-topoisomerase and its limited processivityStructural basis of gate-DNA breakage and resealing by type II topoisomerasesStructure of the N-terminal Gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysisStructural insight into the quinolone-DNA cleavage complex of type IIA topoisomerasesCrystal structure of the DNA gyrase GyrA N-terminal domain fromMycobacterium tuberculosisA novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerasesStructures of Minimal Catalytic Fragments of Topoisomerase V Reveals Conformational Changes Relevant for DNA BindingA domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase functionStructural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA GyraseThe latch modulates nucleotide and DNA binding to the helicase-like domain of Thermotoga maritima reverse gyrase and is required for positive DNA supercoilingA naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogsStructural basis of type II topoisomerase inhibition by the anticancer drug etoposideThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageStructure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activityIdentification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studiesCrystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoilingMechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs: II. THE SHAPE OF THE GyrA SUBUNIT C-TERMINAL DOMAIN (CTD) IS NOT A SOLE DETERMINANT FOR CONTROLLING SUPERCOILING EFFICIENCYStructure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transportOn the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsA New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of InhibitionProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory proteinMycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxesMycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motionToward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platformArabidopsis thaliana GYRB3 does not encode a DNA gyrase subunitExploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesMetal ion and inter-domain interactions as functional networks in E. coli topoisomerase I.Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes.Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification.Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.
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P2860
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
@en
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
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type
label
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
@en
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
@nl
prefLabel
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
@en
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
@nl
P2860
P1476
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.
@en
P2093
Allyn J Schoeffler
James M Berger
P2860
P304
P356
10.1017/S003358350800468X
P577
2008-02-01T00:00:00Z