G protein-coupled receptors. II. Mechanism of agonist activation.
about
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptorsThe TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activationRole for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylationActivation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptidesExpression analysis of G Protein-Coupled Receptors in mouse macrophagesThe second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activationThe receptor concept: pharmacology's big ideaA comprehensive pathway map of epidermal growth factor receptor signalingA second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disordersDopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulationsPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsNon-traditional roles of G protein-coupled receptors in basic cell biologyTurning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug developmentFunctional role of internal water molecules in rhodopsin revealed by X-ray crystallography.Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensorsAgonist induction, conformational selection, and mutant receptorsType IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopySphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218Constitutively active mutants of 5-HT4 receptors are they in unique active states?Production of a bioengineered G-protein coupled receptor of human formyl peptide receptor 3Constitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix sevenModulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipidMolecular dynamics simulations on SDF-1alpha: binding with CXCR4 receptorBihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations.Transmembrane domain IV of the Gallus gallus VT2 vasotocin receptor is essential for forming a heterodimer with the corticotrophin releasing hormone receptorProtein folding: a problem with multiple solutions.C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.Spatial organization of bacteriorhodopsin in model membranes. Light-induced mobility changes.Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5.Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function.Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein.Constraints on the conformation of the cytoplasmic face of dark-adapted and light-excited rhodopsin inferred from antirhodopsin antibody imprints.Residues in the first extracellular loop of a G protein-coupled receptor play a role in signal transduction.Cloning and characterization of the pheromone biosynthesis activating neuropeptide receptor from the silkmoth, Bombyx mori. Significance of the carboxyl terminus in receptor internalization.Conserved aromatic residues in the transmembrane region VI of the V1a vasopressin receptor differentiate agonist vs. antagonist ligand binding.An activation switch in the ligand binding pocket of the C5a receptor.A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinants.Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line.Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor.
P2860
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P2860
G protein-coupled receptors. II. Mechanism of agonist activation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
G protein-coupled receptors. II. Mechanism of agonist activation.
@en
G protein-coupled receptors. II. Mechanism of agonist activation.
@nl
type
label
G protein-coupled receptors. II. Mechanism of agonist activation.
@en
G protein-coupled receptors. II. Mechanism of agonist activation.
@nl
prefLabel
G protein-coupled receptors. II. Mechanism of agonist activation.
@en
G protein-coupled receptors. II. Mechanism of agonist activation.
@nl
P2860
P356
P1476
G protein-coupled receptors. II. Mechanism of agonist activation.
@en
P2093
Kobilka BK
P2860
P304
17979-17982
P356
10.1074/JBC.273.29.17979
P407
P50
P577
1998-07-01T00:00:00Z