Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.
about
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator functionSost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathwaysThe amazing osteocyteSclerostin and occlusion: A brief reviewAccelerated fracture healing with teriparatideFunctions of the osteocyte network in the regulation of bone massApoptotic osteocytes and the control of targeted bone resorptionRole of Irisin on the bone-muscle functional unitRegulation of Wnt/β-catenin signaling within and from osteocytesGenetic evidence that SOST inhibits WNT signaling in the limbMechanotransduction as an Adaptation to Gravity.Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodelingEvidence for pleiotropic factors in genetics of the musculoskeletal systemSingle-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation.Promising bone-related therapeutic targets for rheumatoid arthritis.Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblastsSclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice.Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage.Anabolic therapies.Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended miceSclerostin antibody inhibits skeletal deterioration due to reduced mechanical loadingThe swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutationsOsteocyte Wnt/beta-catenin signaling is required for normal bone homeostasisLoading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disusePeriprosthetic bone density as outcome of therapeutic response.Sclerostin: current knowledge and future perspectives.The impact of simulated and real microgravity on bone cells and mesenchymal stem cellsProtein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.Sclerostin.Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis.A review of osteocyte function and the emerging importance of sclerostinOsteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL-mediated osteoclastogenesis.Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient miceThe myokine irisin increases cortical bone mass.Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation StrategiesBiomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.
P2860
Q24299076-592B21EB-7437-45E8-B2B1-025477A7F0D1Q24309550-C6C55362-CD99-4FA6-9779-03C6F8E00169Q24621990-1770E88B-79DB-4475-92F8-C7BE09CE7F7FQ24635849-35906EEE-3574-405A-A258-B2C5653829E2Q26830392-B8BF92FD-F4DF-42D5-B902-7D664BCD428CQ26862750-6DF6DBFA-1184-495F-9DD2-E39CB6AB47F2Q27002647-CB3A114C-CB8B-4CAB-887A-8A2CF0A8C85DQ27023670-E938C729-0A2A-4DA5-ABFE-77A3D395CAD4Q28068422-9588D079-E4F6-4BAC-BDA7-9E63CAAB4136Q28286814-CCF8097C-B639-4B36-9046-745A0368434BQ28509512-98B918E9-F196-4B40-A25D-4CBC30ED0D4DQ28584642-2F6FD9DB-AF55-4919-B476-C5831234EC02Q28592164-957A027C-101C-496C-8047-412121C19D8FQ28603505-A4A8666C-4D5E-4151-96AA-1C1F16D6560EQ30278695-818B8546-231B-4DF2-8647-746208477A7FQ33554023-5B36F53B-176C-4600-B796-5BAB903D0EC9Q33564617-D645CE19-AD08-4132-9050-6599AC8FAE1DQ33647689-0E7455F5-3E91-458E-B5D5-88BD1597FF79Q33651412-A2C7FFDA-121E-40BD-82EC-7AF5F6417484Q33673894-7E1B06FF-2F90-4267-8C4B-9305301FF577Q33737504-213F4C9F-2F91-4E03-AB29-7AF1062E8F32Q33767244-4F6A51C9-FFCC-4DD4-B1A8-5D41367B78E4Q33825376-BC723CC7-4569-4A53-9A09-CE070B96DD18Q33847609-25719456-1D0B-4477-B10F-5199CE6228D8Q33877602-FE1AA388-C826-44F1-AC1F-195C020C2323Q33920309-D5DBD3F6-41AF-4B92-8887-F0CDD6E506C4Q33965664-B74D0ACC-0526-4169-839E-4EB71E1617CCQ33992612-0413C575-A92A-4A67-8E49-6192FEFCF3FEQ33993217-CDB9290A-0D29-42DB-9E39-687B898E5DE2Q34170640-A252C0B5-3E9A-4658-A089-2D96E694689FQ34211729-F5B07F19-163B-440A-925D-3FF4B2DC2DEFQ34260123-AEFFE1B9-DC24-4A53-96A2-85E41ED00BCAQ34264395-649F921A-D4EF-480C-AE6F-8C1033DDD866Q34328711-E906AB8E-81CE-49D5-86EC-0895A0B10CAFQ34396458-BE5FCF6E-80A2-45ED-86A6-C1C2D6F0EFB5Q34400524-93EE8D70-F021-4705-9DEB-AE7BC73D156AQ34412279-FBE799C6-8F59-443C-B24A-726929298D1AQ34494334-A931CD2D-E742-4306-B8B4-ED0D6D2EE9ABQ34547308-1DD453D9-0C02-4A8D-92C4-89004F8DA542Q34646678-4B1B82AE-7645-4EDB-868E-59B8A34F8E5B
P2860
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@en
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@nl
type
label
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@en
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@nl
prefLabel
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@en
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@nl
P2093
P356
P1476
Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.
@en
P2093
Chuwen Lin
Guoyin Feng
Tujun Weng
Xuan Jiang
Yinghui Li
Zhongquan Dai
P304
P356
10.1359/JBMR.090411
P577
2009-10-01T00:00:00Z