Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. - Wikidata - awgldk - TriplyDB

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

http://www.wikidata.org/entity/Q47871615

about

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways The amazing osteocyte Sclerostin and occlusion: A brief review Accelerated fracture healing with teriparatide Functions of the osteocyte network in the regulation of bone mass Apoptotic osteocytes and the control of targeted bone resorption Role of Irisin on the bone-muscle functional unit Regulation of Wnt/β-catenin signaling within and from osteocytes Genetic evidence that SOST inhibits WNT signaling in the limb Mechanotransduction as an Adaptation to Gravity.Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling Evidence for pleiotropic factors in genetics of the musculoskeletal system Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation.Promising bone-related therapeutic targets for rheumatoid arthritis.Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblasts Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice.Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage.Anabolic therapies.Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse Periprosthetic bone density as outcome of therapeutic response.Sclerostin: current knowledge and future perspectives.The impact of simulated and real microgravity on bone cells and mesenchymal stem cells Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.Sclerostin.Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis.A review of osteocyte function and the emerging importance of sclerostin Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL-mediated osteoclastogenesis.Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice The myokine irisin increases cortical bone mass.Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.

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P2860

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

http://www.wikidata.org/entity/Q47871615

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh-hant

name

Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

@en

Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

@nl

type

label

Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

@en

Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

@nl

prefLabel

Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

@en

Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

@nl

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Sclerostin mediates bone respo ...... ng Wnt/beta-catenin signaling.

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Chuwen Lin

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Guoyin Feng

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Jun Wang

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Lin He

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Tujun Weng

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Xiang Gao

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Xizhi Guo

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Xuan Jiang

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Yinghui Li

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Zhongquan Dai

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1651-1661

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10.1359/JBMR.090411

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19419300

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