about
HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SKSystematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzymeBinding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitorAnalysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis.HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.PKC phosphorylates HEXIM1 and regulates P-TEFb activity.Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathwayCyclin T2 is essential for mouse embryogenesis.Genetic analysis of P-TEFb function via heterologous nucleic acid tethering systems.Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.Long non-coding RNA linc00460 promotes epithelial-mesenchymal transition and cell migration in lung cancer cells.Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.MicroRNA regulation of stem cell fate.Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.Analysis of the genotype-phenotype correlation in patients with phenylketonuria in mainland China.Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Qintong Li
@ast
Qintong Li
@en
Qintong Li
@es
Qintong Li
@nl
Qintong Li
@sl
type
label
Qintong Li
@ast
Qintong Li
@en
Qintong Li
@es
Qintong Li
@nl
Qintong Li
@sl
prefLabel
Qintong Li
@ast
Qintong Li
@en
Qintong Li
@es
Qintong Li
@nl
Qintong Li
@sl
P108
P106
P108
P31
P4012
P496
0000-0002-8447-9770