Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor - Wikidata - awgldk - TriplyDB

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

http://www.wikidata.org/entity/Q24563382

about

The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK Inhibition of Tat activity by the HEXIM1 protein Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK Identification of HEXIM1 as a positive regulator of p53 HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b RNA helicase DDX21 coordinates transcription and ribosomal RNA processing Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme The Drosophila 7SK snRNP and the essential role of dHEXIM in development LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated Regulation of P-TEFb elongation complex activity by CDK9 acetylation Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb P-TEFb goes viral Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186 Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription.SINE RNA induces severe developmental defects in Arabidopsis thaliana and interacts with HYL1 (DRB1), a key member of the DCL1 complex.Cell-type-specific proteome and interactome: using HIV-1 Tat as a test case.Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism Weak preservation of local neutral substitution rates across mammalian genomes.The crystal structure of the 5΄ functional domain of the transcription riboregulator 7SK.Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat Mechanism and factors that control HIV-1 transcription and latency activation Reconstitution of a functional 7SK snRNP Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.Transcriptional and posttranscriptional regulation of HIV-1 gene expression BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

P2860

Q21133696-B29B5807-95A9-47A3-8BF4-EB5EC79169A0 Q21136168-2BBC995D-768B-4EC6-801E-65B22C4026E2 Q21245206-8E845BB2-2445-45A5-9245-5E816DEDEEAA Q24294985-B2B2FB9E-45BB-4039-8314-EBF99BBE9D0E Q24294998-2BB457ED-136E-4852-B964-8F826CB60889 Q24297975-3ED35F77-CE04-4D6C-A9FA-4FD160AAEC33 Q24304885-67983D37-E915-4987-ABDA-CCDF8B2951E5 Q24308066-A1BDBE36-A7B5-4DF7-9A1C-0CFD90D7D079 Q24321455-593F6A83-5853-414E-9C38-0361023ACBA8 Q24597477-282A2018-D9F4-48F5-A881-4057071B9980 Q24646322-78533784-B265-4F3A-88CF-3B8C32B61BD4 Q24675988-C445514A-A132-4BE5-AEC2-00B193329111 Q24684924-CE9DD570-BA64-45F4-8388-754E9996DC80 Q25255186-AA71B8C1-9238-4466-8012-9F3CEAEE9F93 Q26741360-F73A8DB4-19C5-4764-A58A-2CB3A689CF01 Q27647591-8E84E64A-E7AE-4ED9-BD6F-85929D47CA1F Q27728130-DEC907F9-B692-45D7-B1DF-694865845168 Q28240747-BB9E82EF-4C52-4F6A-B8BA-150A5003826F Q28247078-DCF3F505-7E46-4870-9169-69DDAB075265 Q28257440-BB479320-B29C-446F-8A8E-5E8799EF5467 Q28259610-213D6793-A446-4D91-A568-8D0256392331 Q28276848-A6A6A959-5FE4-4BA5-A1BF-E759872324EF Q30409004-7C18F71E-2ACC-45DA-BECF-831E73633690 Q30438975-2051050D-C1FB-497A-A4E7-B3F0244D8040 Q30835037-7F2150E8-B83F-40BA-8532-1314BB92E9F7 Q33343443-2D5D5438-60FC-4C61-9EF6-30F5555E4604 Q33347964-027F06DD-F21A-4521-A246-D0E6BDACCB12 Q33432584-D4FB25E8-7202-44E7-8945-6F8475BA1CBB Q33439248-06289FC6-9533-4621-9736-6AF3B183B620 Q33557347-2BF68DFD-7830-4296-9FF0-347933A96BE8 Q33602605-193D75FD-BDBF-4568-B12D-FA33C223757A Q33608894-3F491637-EF9A-477B-B5E6-1FB6AB60798F Q33614701-DD2B9D83-A2A5-4D76-BE5E-6A5F645B0FC7 Q33702169-D6B3397C-258A-49C3-81C5-4D725219A352 Q33728518-A17A9E76-D536-49E6-8740-9853F7C357D9 Q33826920-259F057C-207E-4556-A8BA-DA0E090942DA Q33878635-E2EBEAE1-0617-4D85-903C-4F41D9278829 Q33947277-691A6895-4747-41AA-8613-9FC3333C057E Q34030804-6AD7B838-95FE-44A6-8735-3FDA6654BFA9 Q34032827-1326465E-0F1B-48ED-9532-2EF1802869D9

P2860

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

http://www.wikidata.org/entity/Q24563382

description

2004 nî lūn-bûn

@nan

2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@ast

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@en

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@nl

type

label

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@ast

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@en

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@nl

prefLabel

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@ast

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@en

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@nl

P1433

Q24563382-5E6696AE-6665-440B-995B-E2519A7DCEC9

P1476

Q24563382-91FCD337-71E0-43E4-A9BC-56F2662F7717

P2093

Q24563382-1E94AB54-22DA-4BDC-9181-A7D21CCCBE6B

Q24563382-33AF610D-3D86-4160-9C2C-AF2097C736B3

Q24563382-37D3EF09-641E-4D9B-AC78-B08451BEC1A4

Q24563382-387B86FE-09FE-4EA8-8E84-36E85B5FE5A5

Q24563382-4D4F788C-4435-4754-AEC1-D511315C7031

Q24563382-98CD5E27-A086-4367-8100-8EA01D8A84C9

Q24563382-D405E14F-A301-47DF-827D-2ADDE7173940

Q24563382-E4C70EC9-0567-4A28-AB21-7435C55B9EA7

Q24563382-EE3B72FD-224D-4E4A-B654-BF57AEFF4C95

P2860

Q24563382-0900A793-8CDC-41D2-9B1A-A2FDD728F33D

Q24563382-0B60B7D7-7CDB-4B23-A8AE-A61B198FF374

Q24563382-0E0C2A07-9EC5-420F-B962-83DA65647BBC

Q24563382-16C952FD-DCB1-41F0-81EF-F7749866B5BF

Q24563382-1945DA6A-5E40-45DD-B07B-EEAF0F21C87F

Q24563382-21789D50-2556-41F4-872D-EF617DBB1061

Q24563382-2DAECF5C-C8A8-4D51-88E2-3694F08174CF

Q24563382-30FCF281-BDDC-4D1E-BAE9-290A63A1B162

Q24563382-350A3031-27C5-4954-8242-4E9328E3C711

Q24563382-373ADEFA-6720-4B41-B961-1648E36FCD90

P304

Q24563382-6B1DC5FE-0A9A-415D-99A7-B0E50567F9D6

P31

Q24563382-B78DE8E2-840C-413E-9C65-A9B8E6248F74

P3181

Q24563382-DA94366B-7C80-4904-889C-E7CDF7C0B66A

P356

Q24563382-D4D3D05A-F860-4BA9-B545-156CA221F16F

P407

Q24563382-4E84D4E2-6AC3-43BB-9289-F9D80FCAC37B

P433

Q24563382-BD782E29-C0D7-49E8-9BD9-ED7515C0FB3F

P478

Q24563382-EB2FCAA3-55DB-4A68-88A4-100C6F5CE309

P50

Q24563382-0A6E3379-3AD9-4F2E-A2E0-D676F385781F

Q24563382-5DAB8FD2-5AF2-44F1-B6CF-D8A9BAF34E4D

P577

Q24563382-452083D8-2A20-4036-BEE0-E7C8165F7E82

P5875

Q24563382-4B42D928-65B0-4C40-AEEC-F9478EB3619D

P698

Q24563382-918EBA1F-48F8-4583-9ED7-9BE05D098292

P932

Q24563382-4E8E9EE4-2735-4754-A5E4-FD1B646A72FB

P3181

P356

SJ.EMBOJ.7600275

P1433

The EMBO Journal

P1476

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

@en

P2093

Alessandro Fraldi

http://www.w3.org/2001/XMLSchema#string

David H Price

http://www.w3.org/2001/XMLSchema#string

François Bonnet

http://www.w3.org/2001/XMLSchema#string

Jason P Price

http://www.w3.org/2001/XMLSchema#string

Luigi Lania

http://www.w3.org/2001/XMLSchema#string

Olivier Bensaude

http://www.w3.org/2001/XMLSchema#string

Stanley C Sedore

http://www.w3.org/2001/XMLSchema#string

Todd E Adamson

http://www.w3.org/2001/XMLSchema#string

Van Trung Nguyen

http://www.w3.org/2001/XMLSchema#string

P2860

Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro

Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

Identification of multiple cyclin subunits of human P-TEFb

Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation

6S RNA regulates E. coli RNA polymerase activity

P304

2608-19

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4705428

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/SJ.EMBOJ.7600275

http://www.w3.org/2001/XMLSchema#string

P407

P433

13

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P50

Annemieke A Michels

P577

2004-07-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8505590

http://www.w3.org/2001/XMLSchema#string

P698

15201869

http://www.w3.org/2001/XMLSchema#string

P932

449783

http://www.w3.org/2001/XMLSchema#string