Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing.
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cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifsVersican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissuesVersican G3 domain regulates neurite growth and synaptic transmission of hippocampal neurons by activation of epidermal growth factor receptorIn situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilageVersican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling.Versican facilitates chondrocyte differentiation and regulates joint morphogenesisExpression of versican V3 by arterial smooth muscle cells alters tumor growth factor β (TGFβ)-, epidermal growth factor (EGF)-, and nuclear factor κB (NFκB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion.Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients.Versican mediates mesenchymal-epithelial transition.Versican isoforms modulate expression and function of nicotinic acetylcholine receptorsA new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features.Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles.Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.Selective activation of the versican promoter by epithelial- mesenchymal interactions during hair follicle developmentVersican: signaling to transcriptional control pathways.Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo.Alternative splicing of the unique "PLUS" domain of chicken PG-M/versican is developmentally regulated.G1 Domain of Versican Regulates Hyaluronan Organization and the Phenotype of Cultured Human Dermal Fibroblasts.Hyaluronan and chondroitin sulfate proteoglycans in the supramolecular organization of the mammalian vitreous body.Versican accumulates in vascular lesions in pulmonary arterial hypertension.Oxidation and modification of extracellular matrix and its role in disease.Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNAVersican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression.Versican V1 isoform regulates cell-associated matrix formation and cell behavior differentially from aggrecan in Swarm rat chondrosarcoma cells.V3 versican isoform alters the behavior of human melanoma cells by interfering with CD44/ErbB-dependent signaling.V3 versican isoform expression has a dual role in human melanoma tumor growth and metastasis.Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensation.Versican V1 isoform induces neuronal differentiation and promotes neurite outgrowthCharacterization of Ovine Dermal Papilla Cell Aggregation.Immortalized, cloned mouse chondrocytic cells (MC615) produce three different matrix proteoglycans with core-protein-specific chondroitin/dermatan sulphate structures.The roles of versican V1 and V2 isoforms in cell proliferation and apoptosis.The proteoglycan lectin domain binds sulfated cell surface glycolipids and promotes cell adhesion.Versican proteolysis mediates myocardial regression during outflow tract development.Glial hyaluronate-binding protein: a product of metalloproteinase digestion of versican?Versican V2 is a major extracellular matrix component of the mature bovine brain.Proteolytic cleavage of versican during cardiac cushion morphogenesis.beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican.Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro.The characterization of versican and its message in human articular cartilage and intervertebral disc.
P2860
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P2860
Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@en
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@nl
type
label
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@en
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@nl
prefLabel
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@en
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@nl
P2093
P2860
P356
P1476
Multiple forms of mouse PG-M, ...... rated by alternative splicing.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.2.958
P407
P577
1995-01-01T00:00:00Z