Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. - Wikidata - awgldk - TriplyDB

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia.

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia.

http://www.wikidata.org/entity/Q48090023

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Human and great ape red blood cells differ in plasmalogen levels and composition Alzheimer's disease as homeostatic responses to age-related myelin breakdown Peroxisomes in brain development and function Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling Sphingolipids and phospholipids in insulin resistance and related metabolic disorders.Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens.Circulating plasmalogen levels and Alzheimer Disease Assessment Scale-Cognitive scores in Alzheimer patients APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease.Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain.Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease.Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo.Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study.Peroxisomal alterations in Alzheimer's disease Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study.Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility.Metabolic system alterations in pancreatic cancer patient serum: potential for early detection.Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction.Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease.Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex.Analytical methods for (oxidized) plasmalogens: Methodological aspects and applications.In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease.Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study Metabolome in progression to Alzheimer's disease.The Effects of Long-Term Saturated Fat Enriched Diets on the Brain Lipidome.Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD).Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.Measurement of Ether Phospholipids in Human Plasma with HPLC-ELSD and LC/ESI-MS After Hydrolysis of Plasma with Phospholipase A1.Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis.Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.APP Function and Lipids: A Bidirectional Link.Serum choline plasmalogens, particularly those with oleic acid in sn-2, are associated with proatherogenic state.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Lipidomics of Alzheimer's disease: current status.Mass spectrometry strategies for clinical metabolomics and lipidomics in psychiatry, neurology, and neuro-oncology.

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P2860

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia.

http://www.wikidata.org/entity/Q48090023

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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name

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

@en

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

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type

label

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

@en

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

@nl

prefLabel

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

@en

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

@nl

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JLR.P700023-JLR200

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Journal of Lipid Research

P1476

Peripheral ethanolamine plasma ...... heimer's disease and dementia.

@en

P2093

Alan Lerner

http://www.w3.org/2001/XMLSchema#string

D L Sparks

http://www.w3.org/2001/XMLSchema#string

Dayan B Goodenowe

http://www.w3.org/2001/XMLSchema#string

Doug Heath

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Dushmanthi A Jayasinghe

http://www.w3.org/2001/XMLSchema#string

John Flax

http://www.w3.org/2001/XMLSchema#string

Jun Liu

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Kevin F Krenitsky

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Kouzin Kamino

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Lisa L Cook

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P2860

Alzheimer's disease: the cholesterol connection

Severe deficiency of docosahexaenoic acid in peroxisomal disorders: a defect of delta 4 desaturation?

Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients

Evidence for a membrane defect in Alzheimer disease brain

Plasmalogens: biosynthesis and functions

Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

Peroxisomal disorders: clinical, biochemical, and molecular aspects.

Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

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2485-2498

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scholarly article

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10.1194/JLR.P700023-JLR200

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11

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48

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2007-07-30T00:00:00Z

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17664527

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P921

Alzheimer's disease