Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.
about
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.PARP inhibition causes premature loss of cohesion in cancer cells.Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers.Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation.Dual Inhibitors of PARPs and ROCKs
P2860
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P2860
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
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2016年學術文章
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name
Structural Basis for Potency and Promiscuity in Poly
@nl
Structural Basis for Potency a ...... ARP) and Tankyrase Inhibitors.
@en
type
label
Structural Basis for Potency and Promiscuity in Poly
@nl
Structural Basis for Potency a ...... ARP) and Tankyrase Inhibitors.
@en
prefLabel
Structural Basis for Potency and Promiscuity in Poly
@nl
Structural Basis for Potency a ...... ARP) and Tankyrase Inhibitors.
@en
P2093
P2860
P1476
Structural Basis for Potency a ...... PARP) and Tankyrase Inhibitors
@en
P2093
Ana Filipa Pinto
Ann-Gerd Thorsell
Lionel Trésaugues
Michael S Cohen
Mirjam Löw
Tobias Karlberg
Torun Ekblad
P2860
P304
P356
10.1021/ACS.JMEDCHEM.6B00990
P407
P577
2016-12-21T00:00:00Z