Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3 - Wikidata - awgldk - TriplyDB

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

http://www.wikidata.org/entity/Q27654592

about

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression PARPs and the DNA damage response Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939 Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4 Crystal Structure of Human ADP-ribose Transferase ARTD15/PARP16 Reveals a Novel Putative Regulatory Domain Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite PARP inhibition: PARP1 and beyond Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Family-wide analysis of poly(ADP-ribose) polymerase activity Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3.Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei.Structural Implications for Selective Targeting of PARPs.Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.PARP inhibitors in cancer therapy: an update.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.Beyond DNA repair, the immunological role of PARP-1 and its siblings.PARP inhibitors: polypharmacology versus selective inhibition.Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone.Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.Identifying Direct Protein Targets of Poly-ADP-Ribose Polymerases (PARPs) Using Engineered PARP Variants-Orthogonal Nicotinamide Adenine Dinucleotide (NAD+) Analog Pairs.Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium.Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

P2860

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P2860

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

http://www.wikidata.org/entity/Q27654592

description

2009 nî lūn-bûn

@nan

2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

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2009年论文

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name

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@ast

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@en

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@nl

type

label

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

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Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@en

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@nl

prefLabel

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@ast

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@en

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

@nl

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Journal of Medicinal Chemistry

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Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

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Alex Flores

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Andreas Johansson

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Natalia Markova

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Olga Loseva

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scholarly article

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10.1021/JM900052J

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9

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52

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Herwig Schüler

Martin Hammarström

Thomas Helleday

Tobias Karlberg

Lovisa Holmberg-Schiavone

Ann-Sofie Jemth

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2009-05-14T00:00:00Z

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19354255

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