Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.
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Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injurySerum S100B: a potential biomarker for suicidality in adolescents?The immune system and developmental programming of brain and behavior.Cellular injury and neuroinflammation in children with chronic intractable epilepsy.Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways.Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury.Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures.An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosisWater maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood.Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injury.Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase.Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells.Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation.Lipopolysaccharide potentiates hyperthermia-induced seizures.Neuropsychopharmacological understanding for therapeutic application of morphinansEvidence of microglial activation in autism and its possible role in brain underconnectivityCytokines and brain excitability.Postnatal inflammation increases seizure susceptibility in adult rats.Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application.Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune systemRole of brain inflammation in epileptogenesis.Human herpes virus 6B: a possible role in epilepsy?Potential for early-life immune insult including developmental immunotoxicity in autism and autism spectrum disorders: focus on critical windows of immune vulnerability.Inflammation in epileptogenesis after traumatic brain injury.Peripheral tumors alter neuroinflammatory responses to lipopolysaccharide in female rats.Inflammation and epilepsy in the developing brain: clinical and experimental evidence.Parkinson's disease: Microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegenerationAttenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.Selective inhibition of microglia-mediated neuroinflammation mitigates radiation-induced cognitive impairment.Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.Inflammation enhances epileptogenesis in the developing rat brainTemporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus.Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats.
P2860
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P2860
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Glial activation links early-l ...... mmatory cytokine upregulation.
@en
Glial activation links early-l ...... mmatory cytokine upregulation.
@nl
type
label
Glial activation links early-l ...... mmatory cytokine upregulation.
@en
Glial activation links early-l ...... mmatory cytokine upregulation.
@nl
prefLabel
Glial activation links early-l ...... mmatory cytokine upregulation.
@en
Glial activation links early-l ...... mmatory cytokine upregulation.
@nl
P2093
P2860
P1433
P1476
Glial activation links early-l ...... mmatory cytokine upregulation.
@en
P2093
Beverley Robin
Cherie Ann Somera
Christopher Anderson
Christy Stine
Heather A Behanna
Kathleen C Somera-Molina
Linda J Van Eldik
Mark S Wainwright
Sookyong Koh
P2860
P304
P356
10.1111/J.1528-1167.2007.01135.X
P577
2007-05-23T00:00:00Z