Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.
about
TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.Genome instabilities arising from ribonucleotides in DNA.The Top1 paradox: Friend and foe of the eukaryotic genome.Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae.Genome integrity and disease prevention in the nervous system.The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.The role of RNase H2 in processing ribonucleotides incorporated during DNA replication.Both R-loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability.CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
P2860
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P2860
Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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name
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@en
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@nl
type
label
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@en
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@nl
prefLabel
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@en
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@nl
P2093
P2860
P356
P1433
P1476
Topoisomerase I-mediated cleav ...... ates DNA double-strand breaks.
@en
P2093
Jessica S Williams
Mercedes E Arana
Shar-Yin N Huang
Thomas A Kunkel
P2860
P304
P356
10.15252/EMBJ.201592426
P407
P50
P577
2016-12-08T00:00:00Z