Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain.
about
Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disordersE Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and DiseaseNeurodevelopment in schizophrenia: the role of the wnt pathways.Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls.Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Transcription factor 4 as an important determinant of gating function in schizophrenia.Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating.Pitt-Hopkins Syndrome.Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficitsActive, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.Data calibration and reduction allows to visualize behavioural profiles of psychosocial influences in mice towards clinical domains.Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex.Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiationAltered gene expression in schizophrenia: findings from transcriptional signatures in fibroblasts and blood.Synaptic Wnt signaling-a contributor to major psychiatric disorders?Meta gene set enrichment analyses link miR-137-regulated pathways with schizophrenia riskCommon variants at VRK2 and TCF4 conferring risk of schizophrenia.Molecular Signatures of Psychosocial Stress and Cognition Are Modulated by Chronic Lithium Treatment.TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disordersConvergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.miR-137: a new player in schizophrenia.TNiK is required for postsynaptic and nuclear signaling pathways and cognitive functionCRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.Impact of TCF4 on the genetics of schizophrenia.Evaluating the links between schizophrenia and sleep and circadian rhythm disruption.TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease.Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription.Role of murine models in psychiatric illness drug discovery: a dimensional view.Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.Kraepelin revisited: schizophrenia from degeneration to failed regeneration.Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex.Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution.Investigation of the role of TCF4 rare sequence variants in schizophrenia.Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in miceFunctional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome.Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets.Clinical and polygraphic improvement of breathing abnormalities after valproate in a case of Pitt-Hopkins syndrome.
P2860
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P2860
Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@en
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@nl
type
label
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@en
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@nl
prefLabel
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@en
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@nl
P2093
P1476
Cognitive and sensorimotor gat ...... bility gene Tcf4 in the brain.
@en
P2093
Konstantin Radyushkin
Magdalena M Brzózka
Moritz J Rossner
Sven P Wichert
P356
10.1016/J.BIOPSYCH.2010.03.015
P407
P577
2010-07-01T00:00:00Z