Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.

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Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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Direct engagement of the PI3K ...... astrointestinal stromal tumor.

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Direct engagement of the PI3K ...... astrointestinal stromal tumor.

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Item

label

Direct engagement of the PI3K ...... astrointestinal stromal tumor.

@en

Direct engagement of the PI3K ...... astrointestinal stromal tumor.

@nl

prefLabel

Direct engagement of the PI3K ...... astrointestinal stromal tumor.

@en

Direct engagement of the PI3K ...... astrointestinal stromal tumor.

@nl

P1476

Direct engagement of the PI3K ...... gastrointestinal stromal tumor

@en

P2093

Andrew Kwok

http://www.w3.org/2001/XMLSchema#string

Benedikt Bosbach

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Cristina R Antonescu

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Ferdinand Rossi

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Georgina Berrozpe

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Imke Ehlers

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Jennifer Loo

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Jennifer Q Zhang

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Katherine Warpinski

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Katia Manova

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P2860

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells

A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal.

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility.

P304

E8448-E8457

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P31

scholarly article

P356

10.1073/PNAS.1711449114

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P407

English

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P478

114

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P50

Darren Veach

P577

2017-09-18T00:00:00Z

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P698

28923937

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P932

5635919

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