Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages
about
Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cellsStructural and functional properties of platelet-derived growth factor and stem cell factor receptorsReceptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timeThe secreted metalloprotease ADAMTS20 is required for melanoblast survivalThe C-kit receptor-mediated signal transduction and tumor-related diseasesThe structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): an in silico analysis.Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesisc-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis.Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.Lipid rafts are required for Kit survival and proliferation signalsSH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in micePrimordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating alleleRole of thrombopoietin in mast cell differentiation.Recent discoveries in the genetics of melanoma and their therapeutic implications.Green fluorescent protein transgene driven by Kit regulatory sequences is expressed in hematopoietic stem cells.A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis.Thrombopoietin inhibits murine mast cell differentiation.Therapeutic targeting of c-KIT in cancer.KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways.KIT signaling governs differential sensitivity of mature and primitive CML progenitors to tyrosine kinase inhibitors.Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells.Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond.Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development.The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.
P2860
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P2860
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages
description
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2004
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im April 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/04/20)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/04/20)
@nl
наукова стаття, опублікована у квітні 2004
@uk
name
Targeted mutations of the juxt ...... affect multiple cell lineages
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Targeted mutations of the juxt ...... affect multiple cell lineages
@en
Targeted mutations of the juxt ...... affect multiple cell lineages
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type
label
Targeted mutations of the juxt ...... affect multiple cell lineages
@ast
Targeted mutations of the juxt ...... affect multiple cell lineages
@en
Targeted mutations of the juxt ...... affect multiple cell lineages
@nl
prefLabel
Targeted mutations of the juxt ...... affect multiple cell lineages
@ast
Targeted mutations of the juxt ...... affect multiple cell lineages
@en
Targeted mutations of the juxt ...... affect multiple cell lineages
@nl
P2093
P2860
P3181
P356
P1476
Targeted mutations of the juxt ...... affect multiple cell lineages
@en
P2093
Alan Bernstein
Jason B. Cohn
Jeffrey L. Wrana
Kazunobu Tachibana
Masanori Hirashima
Michael Klüppel
Nina Jones
Yuki Kimura
P2860
P304
P3181
P356
10.1073/PNAS.0305363101
P407
P577
2004-04-20T00:00:00Z