Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
about
Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteinsCollapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, and conformational flexibility.Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury.Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacChimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons.(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias(Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currentsChallenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia.The Role of Cdk5 in Alzheimer's Disease.Regulation of dendritic development by semaphorin 3A through novel intracellular remote signaling.Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.CHARACTERIZING CALCIUM INFLUX VIA VOLTAGE- AND LIGAND-GATED CALCIUM CHANNELS IN EMBRYONIC ALLIGATOR NEURONS IN CULTURE.The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state.CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone.PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes.CRMP2-Neurofibromin Interface Drives NF1-related Pain.CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain
P2860
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P2860
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@en
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@nl
type
label
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@en
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@nl
prefLabel
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@en
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@nl
P2093
P2860
P1433
P1476
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
@en
P2093
Joel M Brittain
Omotore Eruvwetere
Yuying Wang
P2860
P304
P356
10.1016/J.FEBSLET.2012.09.022
P407
P577
2012-09-26T00:00:00Z