A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.
about
Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cellsHereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of diseaseTargeting BMP signalling in cardiovascular disease and anaemiaAnimal Models in Studying Cerebral Arteriovenous MalformationBMPs and their clinical potentialsImaging of small animal peripheral artery disease models: recent advancements and translational potentialVascular anomalies: from genetics toward models for therapeutic trialsMononuclear cells and vascular repair in HHTALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.Matrix Gla protein deficiency causes arteriovenous malformations in miceALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expressionPhase I study of PF-03446962, a fully human monoclonal antibody against activin receptor-like kinase-1, in patients with hepatocellular carcinoma.Biology of vascular malformations of the brain.Endoglin in liver fibrogenesis: Bridging basic science and clinical practiceBrain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets.Molecular pathways: can activin-like kinase pathway inhibition enhance the limited efficacy of VEGF inhibitors?Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes.Shear induced collateral artery growth modulated by endoglin but not by ALK1.The pathobiology of vascular malformations: insights from human and model organism genetics.Transforming growth factor-β and the hallmarks of cancer.Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the diseaseArteriovenous malformation in the adult mouse brain resembling the human disease.Contribution of oxidative stress to endothelial dysfunction in hereditary hemorrhagic telangiectasia.ALK1 as an emerging target for antiangiogenic therapy of cancerMatrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency.Manipulating angiogenesis in medicine.Hereditary hemorrhagic telangiectasia: an overview of diagnosis and management in the molecular era for clinicians.Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brainHereditary hemorrhagic telangiectasia, a vascular dysplasia affecting the TGF-beta signaling pathwayDifferentiation of arterial and venous endothelial cells and vascular morphogenesis.Oxidative stress contributes to endothelial dysfunction in mouse models of hereditary hemorrhagic telangiectasia.Endoglin: a critical mediator of cardiovascular healthPulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.From germline towards somatic mutations in the pathophysiology of vascular anomalies.The TGF-beta paradox in human cancer: an update.Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression.Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations.
P2860
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P2860
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.
@en
A mouse model for hereditary hemorrhagic telangiectasia
@nl
type
label
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.
@en
A mouse model for hereditary hemorrhagic telangiectasia
@nl
prefLabel
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.
@en
A mouse model for hereditary hemorrhagic telangiectasia
@nl
P2093
P356
P1476
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2
@en
P2093
Douglas A Marchuk
Laura P Hale
Martha A Hanes
Mary E M Porteous
Tayeashai Dickens
P304
P356
10.1093/HMG/DDG050
P577
2003-03-01T00:00:00Z