ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
about
Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cellsCasein kinase 2beta as a novel enhancer of activin-like receptor-1 signalingBone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cellsExpression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cellsHereditary haemorrhagic telangiectasia: a clinical and scientific reviewPreclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancerAnimal Models in Studying Cerebral Arteriovenous MalformationBMPs and their clinical potentialsVascular anomalies: from genetics toward models for therapeutic trialsEndothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous systemExcessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switchEnhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesisTransforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function.Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia.Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.Interaction between alk1 and blood flow in the development of arteriovenous malformationsDeletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.Biology of vascular malformations of the brain.ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.Stromal regulation of vessel stability by MMP14 and TGFbeta.Molecular pathways: can activin-like kinase pathway inhibition enhance the limited efficacy of VEGF inhibitors?De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulationSpectral imaging reveals microvessel physiology and function from anastomoses to thromboses.Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes.BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.The pathobiology of vascular malformations: insights from human and model organism genetics.ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.Directional next-generation RNA sequencing and examination of premature termination codon mutations in endoglin/hereditary haemorrhagic telangiectasiaDynamic analysis of BMP-responsive smad activity in live zebrafish embryosArteriovenous malformation in the adult mouse brain resembling the human disease.Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging miceOrgan specific optical imaging of mitochondrial redox state in a rodent model of hereditary hemorrhagic telangiectasia-1Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation.ALK1 as an emerging target for antiangiogenic therapy of cancerEndothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton.
P2860
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P2860
ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
description
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Januar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/01/15)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/01/15)
@nl
наукова стаття, опублікована в січні 2008
@uk
مقالة علمية (نشرت في 15-1-2008)
@ar
name
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@ast
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@en
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@nl
type
label
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@ast
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@en
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@nl
prefLabel
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@ast
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@en
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@nl
P2093
P2860
P50
P921
P1433
P1476
ALK5- and TGFBR2-independent r ...... orrhagic telangiectasia type 2
@en
P2093
Alice Park
Naime Fliess
Sung O Park
Tsugio Seki
Xiaofang Wu
Young Jae Lee
Zhigang Jiang
P2860
P304
P356
10.1182/BLOOD-2007-08-107359
P407
P577
2007-10-02T00:00:00Z