Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.
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Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity.Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicityGlial cells as intrinsic components of non-cell-autonomous neurodegenerative diseaseBergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic micePrecision medicine in spinocerebellar ataxias: treatment based on common mechanisms of diseaseAstrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous SystemCharcot-Marie-Tooth disease and intracellular trafficMouse models of polyglutamine diseases: review and data table. Part IGenetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type CCerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase ActivityAstrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neuronsThe insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disordersExpression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Cerebellar defects in a mouse model of juvenile neuronal ceroid lipofuscinosis.Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in ratsPurkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 modelMolecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegenerationGlial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila modelsConditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration.The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1Profiling the genes affected by pathogenic TDP-43 in astrocytesMutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease miceLoss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophyNeighbor effects of neurons bearing protective transgenesIn vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 miceProteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease.Autophagy, inflammation and neurodegenerative disease.What can pluripotent stem cells teach us about neurodegenerative diseases?Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.Glial S100B protein modulates mutant ataxin-1 aggregation and toxicity: TRTK12 peptide, a potential candidate for SCA1 therapyEarly activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.The role of the immune system in triplet repeat expansion diseasesSox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellumWidespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
P2860
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P2860
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Bergmann glia expression of po ...... impairing glutamate transport.
@en
Bergmann glia expression of po ...... impairing glutamate transport.
@nl
type
label
Bergmann glia expression of po ...... impairing glutamate transport.
@en
Bergmann glia expression of po ...... impairing glutamate transport.
@nl
prefLabel
Bergmann glia expression of po ...... impairing glutamate transport.
@en
Bergmann glia expression of po ...... impairing glutamate transport.
@nl
P2093
P356
P1433
P1476
Bergmann glia expression of po ...... impairing glutamate transport.
@en
P2093
Albert R La Spada
Bryce L Sopher
Christian Schultz
Gwenn A Garden
Lesnick E Westrum
Nishi Gill
Randell T Libby
Sara K Custer
Stephan J Guyenet
Thomas Deller
P2888
P304
P356
10.1038/NN1750
P407
P577
2006-08-27T00:00:00Z