In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.
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Endogenous opiates and behavior: 2006Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis.Differences between opioids: pharmacological, experimental, clinical and economical perspectivesChallenges for blood-brain barrier (BBB) screening.Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery.Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats.Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport.Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.Sulfation of opioid drugs by human cytosolic sulfotransferases: metabolic labeling study and enzymatic analysis.Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier modelEffects of perinatal oxycodone exposure on the cardiovascular response to acute stress in male rats at weaning and in young adulthood.The development of multiple probe microdialysis sampling in the stomachOn the rate and extent of drug delivery to the brain.Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approachThe influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheepG protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.Oxycodone for the treatment of postoperative pain.Application of population pharmacokinetics for preclinical safety and efficacy studies.Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions.Perspectives on Intravenous Oxycodone for Control of Postoperative Pain.Pharmacokinetic and pharmacodynamic evaluation of oxycodone and naltrexone for the treatment of chronic lower back pain.Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.Study on the activation of the opioid receptors by a set of morphine derivatives in a well-defined assay system.Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic Model.Revisiting atenolol as a low passive permeability marker.The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse.Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration.Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study.Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer-Which Factors Matter?Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine.Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study.Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic.Application of Microdialysis for Pharmacokinetics of Traditional Chinese Medicine Studies
P2860
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P2860
In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
In vivo blood-brain barrier tr ...... macokinetics/pharmacodynamics.
@en
In vivo blood-brain barrier tr ...... macokinetics/pharmacodynamics.
@nl
type
label
In vivo blood-brain barrier tr ...... macokinetics/pharmacodynamics.
@en
In vivo blood-brain barrier tr ...... macokinetics/pharmacodynamics.
@nl
prefLabel
In vivo blood-brain barrier tr ...... macokinetics/pharmacodynamics.
@en
In vivo blood-brain barrier tr ...... macokinetics/pharmacodynamics.
@nl
P356
P1476
In vivo blood-brain barrier tr ...... rmacokinetics/pharmacodynamics
@en
P2093
Emma Boström
Margareta Hammarlund-Udenaes
P304
P356
10.1124/DMD.106.009746
P577
2006-06-08T00:00:00Z