Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.

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Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.

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Q46243170-04BF0554-4963-4895-914C-D808EA16F00F

P2860

Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年學術文章

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Quantitative projection of hum ...... ng and PET receptor occupancy.

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Quantitative projection of hum ...... ng and PET receptor occupancy.

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Quantitative projection of hum ...... ng and PET receptor occupancy.

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Quantitative projection of hum ...... ng and PET receptor occupancy.

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Quantitative projection of hum ...... ng and PET receptor occupancy.

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Quantitative projection of hum ...... ng and PET receptor occupancy.

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P1476

Quantitative projection of hum ...... ng and PET receptor occupancy.

@en

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Aarti Sawant-Basak

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Anne Schmidt

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Christopher L Shaffer

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David Labaree

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Donna Palumbo

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Douglas K Spracklin

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Elaine Tseng

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Jean-Dominique Gallezot

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Laigao Chen

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Nabeel Nabulsi

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P2860

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

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Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner

Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study.

Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics.

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Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.

Translational PET imaging research.

Diphenhydramine has similar interspecies net active influx at the blood-brain barrier.

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyc

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119-126

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scholarly article

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10.3109/00498254.2016.1166531

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English

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P478

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2016-06-29T00:00:00Z

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P698

27353353

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Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.

about

P2860

P2860

Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.

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P478

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P698