Peripheral cocaine-blocking agents: new medications for cocaine dependence. An introduction to immunological and enzymatic approaches to treating cocaine dependence reported by Fox, Gorelick and Cohen in the immediately succeeding articles (see page
about
Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.First-principle studies of intermolecular and intramolecular catalysis of protonated cocaine.Rational design of an enzyme mutant for anti-cocaine therapeuticsFirst-principles calculation of pKa for cocaine, nicotine, neurotransmitters, and anilines in aqueous solution.Computational redesign of human butyrylcholinesterase for anticocaine medication.Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityCatalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaineTherapeutic vaccines for substance dependence.Ethical issues in using a cocaine vaccine to treat and prevent cocaine abuse and dependence.How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation.Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-CocaineFree-energy perturbation simulation on transition states and redesign of butyrylcholinesterase.Human butyrylcholinesterase-cocaine binding pathway and free energy profiles by molecular dynamics and potential of mean force simulations.Reaction pathway and free energy profile for prechemical reaction step of human butyrylcholinesterase-catalyzed hydrolysis of (-)-cocaine by combined targeted molecular dynamics and potential of mean force simulations.Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulationsComputational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation.Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants.Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesteraseCocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations.Computational design of a thermostable mutant of cocaine esterase via molecular dynamics simulations.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants.Density functional theory investigation of cocaine water complexes.
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Peripheral cocaine-blocking agents: new medications for cocaine dependence. An introduction to immunological and enzymatic approaches to treating cocaine dependence reported by Fox, Gorelick and Cohen in the immediately succeeding articles (see page
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Peripheral cocaine-blocking ag ...... succeeding articles (see page
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Peripheral cocaine-blocking ag ...... succeeding articles (see page
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type
label
Peripheral cocaine-blocking ag ...... succeeding articles (see page
@en
Peripheral cocaine-blocking ag ...... succeeding articles (see page
@nl
prefLabel
Peripheral cocaine-blocking ag ...... succeeding articles (see page
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Peripheral cocaine-blocking ag ...... succeeding articles (see page
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P1476
Peripheral cocaine-blocking ag ...... g articles (see pages 153-174)
@en
P2093
P304
P356
10.1016/S0376-8716(97)00072-0
P577
1997-12-01T00:00:00Z