Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulations
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Monoamine transporters: insights from molecular dynamics simulationsInsights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDATThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsModeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuseModulation by cocaine of dopamine receptors through miRNA-133b in zebrafish embryosExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics StudyInsights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocationAllosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.Muscarinic type 2 receptors in the lateral dorsal tegmental area modulate cocaine and food seeking behavior in ratsDiscovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporterMutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelInteraction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113.Enzyme-therapy approaches for the treatment of drug overdose and addiction.Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose?Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeMolecular mechanism of HIV-1 Tat interacting with human dopamine transporter.Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective.Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinationsThe binding sites for benztropines and dopamine in the dopamine transporter overlap.Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood.HIV-1 transgenic rats display an increase in [(3)H]dopamine uptake in the prefrontal cortex and striatum.Computational modeling of human dopamine transporter structures, mechanism and its interaction with HIV-1 transactivator of transcription.Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter.Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulationThe role of human dopamine transporter in NeuroAIDS.The molecular basis of talin2's high affinity toward β1-integrin.Molecular basis of the selectivity of the immunoproteasome catalytic subunit LMP2-specific inhibitor revealed by molecular modeling and dynamics simulations.Anhydroecgonine Methyl Ester (AEME), a Product of Cocaine Pyrolysis, Impairs Spatial Working Memory and Induces Striatal Oxidative Stress in Rats.
P2860
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P2860
Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulations
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Mechanism for cocaine blocking ...... eling and dynamics simulations
@en
Mechanism for cocaine blocking ...... ling and dynamics simulations.
@nl
type
label
Mechanism for cocaine blocking ...... eling and dynamics simulations
@en
Mechanism for cocaine blocking ...... ling and dynamics simulations.
@nl
prefLabel
Mechanism for cocaine blocking ...... eling and dynamics simulations
@en
Mechanism for cocaine blocking ...... ling and dynamics simulations.
@nl
P2093
P2860
P356
P1476
Mechanism for cocaine blocking ...... eling and dynamics simulations
@en
P2093
Chang-Guo Zhan
Howard H Gu
Xiaoqin Huang
P2860
P304
15057-15066
P356
10.1021/JP900963N
P407
P577
2009-11-01T00:00:00Z