Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.
about
C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosisComplexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagminsComplexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helixComplexins: small but capableActivity-dependent, homeostatic regulation of neurotransmitter release from auditory nerve fibers.The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearingNew insights into cochlear sound encodingDecreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorderSynaptic vesicles position complexin to block spontaneous fusionStructural Changes and Lack of HCN1 Channels in the Binaural Auditory Brainstem of the Naked Mole-Rat (Heterocephalus glaber).Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin.Relating structure and function of inner hair cell ribbon synapses.Morphological and physiological development of auditory synapses.Optogenetic stimulation of the auditory pathway.Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications.Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.Molecular anatomy of the hair cell's ribbon synapseControl of exocytosis by synaptotagmins and otoferlin in auditory hair cells.Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate ComplexinsEnrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish developmentExocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.The SNARE complex in neuronal and sensory cells.Stochastic properties of neurotransmitter release expand the dynamic range of synapsesComplexin2 modulates working memory-related neural activity in patients with schizophrenia.Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity.Molecular underpinnings of synaptic vesicle pool heterogeneity.Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexinStabilization of spontaneous neurotransmitter release at ribbon synapses by ribbon-specific subtypes of complexinInteraction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp.Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutantTilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.Neural circuit development in the mammalian cochlea.Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.Synaptic plasticity in the auditory system: a review.Molecular mechanisms governing Ca(2+) regulation of evoked and spontaneous release.Auditory neuropathy--neural and synaptic mechanisms.Calcium dependence of spontaneous neurotransmitter release.Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.
P2860
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P2860
Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Complexin-I is required for hi ...... bulb of Held auditory synapse.
@en
Complexin-I is required for hi ...... bulb of Held auditory synapse.
@nl
type
label
Complexin-I is required for hi ...... bulb of Held auditory synapse.
@en
Complexin-I is required for hi ...... bulb of Held auditory synapse.
@nl
prefLabel
Complexin-I is required for hi ...... bulb of Held auditory synapse.
@en
Complexin-I is required for hi ...... bulb of Held auditory synapse.
@nl
P2093
P1476
Complexin-I is required for hi ...... dbulb of Held auditory synapse
@en
P2093
Andreas Neef
Anna V Bulankina
Cornelia Kopp-Scheinpflug
Darina Khimich
Kerstin Reim
Matthew A Xu-Friedman
Nicola Strenzke
Nils Brose
P304
P356
10.1523/JNEUROSCI.0632-09.2009
P407
P577
2009-06-01T00:00:00Z