Proliferation of human malignant astrocytomas is dependent on Ras activation.
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Abstracts for the Thirteenth Annual Meeting of the Society for Neuro-OncologyDesign of versatile biochemical switches that respond to amplitude, duration, and spatial cuesMolecular characterizations of glioblastoma, targeted therapy, and clinical results to dateCurrent Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible CrosstalkThe future role of personalized medicine in the treatment of glioblastoma multiformeThe N-terminal domain of ERK1 accounts for the functional differences with ERK2Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesMultiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastomaH-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathwayCooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis.Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis.Integration of pathway structure information into a reweighted partial Cox regression approach for survival analysis on high-dimensional gene expression data.Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.Emerging role of new transgenic mouse models in glioma research.EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion.Retinoblastoma loss modulates DNA damage response favoring tumor progressionContribution of tumor heterogeneity in a new animal model of CNS tumors.Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies.Intracranial gliomas in neurofibromatosis type 1.A graphic method for identification of novel glioma related genes.Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis.R-RAS2 overexpression in tumors of the human central nervous system.Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesisAnti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model.Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications.The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats.A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.A positive feedback loop couples Ras activation and CD44 alternative splicingA GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.Akt signaling is required for glioblastoma maintenance in vivoNG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.Genes and pathways driving glioblastomas in humans and murine disease models.RasGRP3 regulates the migration of glioma cells via interaction with Arp3Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cellsInhibitors of Glioma Growth that Reveal the Tumour to the Immune System.Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: Growth factor and Ras signaling pathways.Organ donors with malignant gliomas: an update.A Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities.
P2860
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P2860
Proliferation of human malignant astrocytomas is dependent on Ras activation.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@en
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@nl
type
label
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@en
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@nl
prefLabel
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@en
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@nl
P2093
P356
P1433
P1476
Proliferation of human malignant astrocytomas is dependent on Ras activation.
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1201455
P407
P577
1997-12-01T00:00:00Z