Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q48624391

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Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.VH-VL orientation prediction for antibody humanization candidate selection: A case study.Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model.Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency Early investigational drugs targeting tau protein for the treatment of Alzheimer's disease Tau aggregation and its interplay with amyloid-β.Detecting tau in serum of transgenic animal models after tau immunotherapy treatment.Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies.Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.Therapy and clinical trials in frontotemporal dementia: past, present, and future.Tau passive immunization inhibits not only tau but also Aβ pathology Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope.Invited review: Drug development for tauopathies.Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium.Region-specific permeability of the blood-brain barrier upon pericyte loss.A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.Emerging amyloid and tau targeting treatments for Alzheimer's disease.A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies.Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach Emerging Diagnostic and Therapeutic Strategies for Tauopathies.Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.Tau Proteins and Tauopathies in Alzheimer's Disease.High-resolution Confocal Imaging of the Blood-brain Barrier: Imaging, 3D Reconstruction, and Quantification of Transcytosis.Tauopathies: Mechanisms and Therapeutic Strategies.RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration.Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice.Tau-based therapies in neurodegeneration: opportunities and challenges.Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau.Vaccination strategies in tauopathies and synucleinopathies.Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies.Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy.Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders.Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

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Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q48624391

description

2014 nî lūn-bûn

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name

Neuronal uptake of tau/pS422 a ...... model of Alzheimer's disease.

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Neuronal uptake of tau/pS422 a ...... model of Alzheimer's disease.

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Neuronal uptake of tau/pS422 a ...... model of Alzheimer's disease.

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Bernd Bohrmann

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Fiona Grüninger

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Krisztina Oroszlan-Szovik

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Laurence Ozmen

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Ludovic Collin

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Ulrich Göpfert

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P2860

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

Transmission and spreading of tauopathy in transgenic mouse brain

Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development

Trans-synaptic spread of tau pathology in vivo

Propagation of tau pathology in a model of early Alzheimer's disease

Tau filament formation in transgenic mice expressing P301L tau.

Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

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Pt 10

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137

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25085375

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Alzheimer's disease