Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicityVitamin A and Alzheimer's diseaseAlzheimer's disease as homeostatic responses to age-related myelin breakdownProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsSynthetic amyloid-beta oligomers impair long-term memory independently of cellular prion proteinSoluble oligomers of the amyloid beta-protein impair synaptic plasticity and behaviorLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in miceReelin signaling antagonizes beta-amyloid at the synapseAmyloids: friend or foe?Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptakeSynapses and Alzheimer's diseaseThe Rationale for Insulin Therapy in Alzheimer's DiseaseTargeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeuticsPathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseApolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer diseaseNeuropathological alterations in Alzheimer diseaseIntracellular cleavage of amyloid β by a viral protease NIa prevents amyloid β-mediated cytotoxicityMT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid -related Behavioral Deficits in a Mouse Model of Alzheimer DiseaseX-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ 17–36Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent AutophagyDeletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's diseaseCompetitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and ToxicityLarge aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugationNumerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic SynapsesInhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein.Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.Cognitive effects of cell-derived and synthetically derived Aβ oligomers.Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation.Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.The concentration of soluble extracellular amyloid-β protein in acute brain slices from CRND8 mice.Autoinsertion of soluble oligomers of Alzheimer's Abeta(1-42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface.Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.
P2860
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P2860
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Effects of secreted oligomers ...... ty: a potent role for trimers.
@en
Effects of secreted oligomers ...... ty: a potent role for trimers.
@nl
type
label
Effects of secreted oligomers ...... ty: a potent role for trimers.
@en
Effects of secreted oligomers ...... ty: a potent role for trimers.
@nl
prefLabel
Effects of secreted oligomers ...... ty: a potent role for trimers.
@en
Effects of secreted oligomers ...... ty: a potent role for trimers.
@nl
P2093
P2860
P1476
Effects of secreted oligomers ...... ty: a potent role for trimers.
@en
P2093
Dennis J Selkoe
Dominic M Walsh
Ganesh M Shankar
Matthew Townsend
Tapan Mehta
P2860
P304
P356
10.1113/JPHYSIOL.2005.103754
P407
P577
2006-02-09T00:00:00Z