Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

http://www.wikidata.org/entity/Q30490690

about

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.Lysosomal adaptation: how the lysosome responds to external cues Classification of subcellular location by comparative proteomic analysis of native and density-shifted lysosomes Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis An overview of APP processing enzymes and products.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Signals from the lysosome: a control centre for cellular clearance and energy metabolism.Higher levels of cystatin C are associated with worse cognitive function in older adults with chronic kidney disease: the chronic renal insufficiency cohort cognitive study.Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.Protective mechanisms by cystatin C in neurodegenerative diseases.A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model Autophagy failure in Alzheimer's disease--locating the primary defect.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Measurement of cystatin C levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis.Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.Cystatin C in Alzheimer's disease.Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.Autophagy and neuronal cell death in neurological disorders Expression, purification, and characterization of human cystatin C monomers and oligomers.Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein Fertility defects in mice expressing the L68Q variant of human cystatin C: a role for amyloid in male infertility.Alzheimer's disease and the amyloid-beta peptide.Developmental regulation of synthesis and dimerization of the amyloidogenic protease inhibitor cystatin C in the hematopoietic system.Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models?Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?Control of autophagy as a therapy for neurodegenerative disease.Proteolytic degradation of amyloid β-protein.

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P2860

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

http://www.wikidata.org/entity/Q30490690

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Cystatin C-cathepsin B axis re ...... model of Alzheimer's disease.

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Cystatin C-cathepsin B axis re ...... model of Alzheimer's disease.

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Anders Grubb

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Binggui Sun

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Brian Halabisky

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Iris Lo

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Li Gan

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Sarah Mueller-Steiner

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Seo-Hyun Cho

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Xin Wang

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Yungui Zhou

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids

Cystatin C modulates cerebral beta-amyloidosis

Pathways towards and away from Alzheimer's disease

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

Elevation of cystatin C in susceptible neurons in Alzheimer's disease

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