Chris Lipinski discusses life and chemistry after the Rule of Five.
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A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System TargetsExperimental and computational active site mapping as a starting point to fragment-based lead discoveryApplication of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1)Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro studyNovel chemical space exploration via natural productsIntegration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?Fragment-based screening using surface plasmon resonance technology.FragmentStore--a comprehensive database of fragments linking metabolites, toxic molecules and drugs.Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues.Small-molecule inhibitors of the receptor tyrosine kinases: promising tools for targeted cancer therapiesBDDCS applied to over 900 drugs.Development of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs.Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazoneCombining intracellular selection with protein-fragment complementation to derive Aβ interacting peptides.Perspectives on NMR in drug discovery: a technique comes of ageMaking cardiomyocytes with your chemistry set: Small molecule-induced cardiogenesis in somatic cells.L-Asparaginase as a new molecular target against leishmaniasis: insights into the mechanism of action and structure-based inhibitor design.Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia.Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors.Overview of computational methods employed in early-stage drug discovery.Computational elucidation, Mutational and Hot spot-based designing of potential inhibitors against human acid-sensing ion channels (hASIC-1a) to treatment of various physiological conditions.Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening, ADMET prediction and molecular dynamics simulation assay.Understanding brain penetrance of anticancer drugs.
P2860
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P2860
Chris Lipinski discusses life and chemistry after the Rule of Five.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Chris Lipinski discusses life and chemistry after the Rule of Five.
@en
Chris Lipinski discusses life and chemistry after the Rule of Five.
@nl
type
label
Chris Lipinski discusses life and chemistry after the Rule of Five.
@en
Chris Lipinski discusses life and chemistry after the Rule of Five.
@nl
prefLabel
Chris Lipinski discusses life and chemistry after the Rule of Five.
@en
Chris Lipinski discusses life and chemistry after the Rule of Five.
@nl
P1433
P1476
Chris Lipinski discusses life and chemistry after the Rule of Five.
@en
P356
10.1016/S1359-6446(02)02556-4
P577
2003-01-01T00:00:00Z