Badapple: promiscuity patterns from noisy evidence.Navigating chemical space for biology and medicineParallel worlds of public and commercial bioactive chemistry dataComputational prediction and validation of an expert's evaluation of chemical probesA crowdsourcing evaluation of the NIH chemical probesRule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions.Drug-like properties and the causes of poor solubility and poor permeability.Single-mode compound retrieval for QSAR, QSPR data sets, and batch mode exact structure searching.Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis.Small molecules with antiviral activity against the Ebola virusThermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.The anti-intellectual effects of intellectual property.Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.Lead- and drug-like compounds: the rule-of-five revolution.Medicinal chemistry of aldose reductase inhibitors.Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.Pseudosymmetry and bioisosterism in biaryl pyridyl competitive histamine H2-receptor antagonists.The rule of five should not impede anti-parasitic drug developmentBioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists.Bioisosteric design of conformationally restricted pyridyltriazole histamine H2-receptor antagonists.High throughput sonication: evaluation for compound solubilization.Chris Lipinski discusses life and chemistry after the Rule of Five.Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida.MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.Erratum: A crowdsourcing evaluation of the NIH chemical probesChemical Tools for Indications Discovery
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P50
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medicinal chemist
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Christopher A. Lipinski
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Christopher A. Lipinski
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Christopher A. Lipinski
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Christopher Lipinski
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Christopher Lipinski
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克里斯多夫·里宾斯基
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克里斯多夫·里宾斯基
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克里斯多夫·里宾斯基
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克里斯多夫·里賓斯基
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Christopher A. Lipinski
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Christopher A. Lipinski
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Christopher A. Lipinski
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Christopher Lipinski
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Christopher Lipinski
@sl
克里斯多夫·里宾斯基
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克里斯多夫·里宾斯基
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克里斯多夫·里宾斯基
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克里斯多夫·里賓斯基
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Chris Lipinski
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Christopher Lipinski
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Christopher Lipinski
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Christopher A. Lipinski
@en
Christopher A. Lipinski
@es
Christopher A. Lipinski
@nl
Christopher Lipinski
@fr
Christopher Lipinski
@sl
克里斯多夫·里宾斯基
@zh
克里斯多夫·里宾斯基
@zh-cn
克里斯多夫·里宾斯基
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克里斯多夫·里賓斯基
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0000-0001-7355-7254
P569
2000-01-01T00:00:00Z