Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?
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Nitroglycerin-induced nNOS increase in rat trigeminal nucleus caudalis is inhibited by systemic administration of lysine acetylsalicylate but not of sumatriptanNon-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalisSensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology.The neurobiology of migraine.Migraine pharmacotherapy with oral triptans: a rational approach to clinical management.The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.Review of zolmitriptan and its clinical applications in migraine.Pearls and pitfalls in experimental in vivo models of migraine: dural trigeminovascular nociception.Finding new drug targets for the treatment of migraine attacks.Effects of a selective 5-HT(1B/1D) receptor agonist on spinal and trigeminal reflexes in the anaesthetized rabbit.The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn.Migraine pathophysiology.Does sumatriptan cross the blood-brain barrier in animals and man?New migraine and pain research.Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine.The blood-brain barrier in migraine treatment.Migraine in the triptan era: progresses achieved, lessons learned and future developments.Insights into the pharmacological targeting of the trigeminocervical complex in the context of treatments of migraine.Animal migraine models for drug development: status and future perspectives.Autoradiographic Mapping of 5-HT(1B/1D) Binding Sites in the Rhesus Monkey Brain Using [carbonyl-C]zolmitriptan.An update on migraine: current understanding and future directions.Pathophysiology of Migraine: A Disorder of Sensory Processing.Zolmitriptan orally disintegrating tablet is effective in the acute treatment of migraine.Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptanPre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine.On the role of 5-HT1B/1D receptors in modulating transmission in a spinal reflex pathway in the decerebrated rabbit.Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat.Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine.Safety trial with the 5HT1B/1D agonist avitriptan (BMS-180048) in patients with migraine who have experienced pressure, tightness, and/or pain in the chest, neck, and/or throat following sumatriptan.Dural vasodilation causes a sensitization of rat caudal trigeminal neurones in vivo that is blocked by a 5-HT1B/1D agonist.Distribution of intranasal C-zolmitriptan assessed by positron emission tomography.TRPV1 receptor blockade is ineffective in different in vivo models of migraine.Persistence of attacks of cluster headache after trigeminal nerve root section.Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2.Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects.Selective decrease in serotonin synthesis rate in rat brainstem raphe nuclei following chronic administration of low doses of amitriptyline: an effect compatible with an anti-migraine effect.A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers.Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain.
P2860
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P2860
Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Inhibition of trigeminal neuro ...... herapeutic target in migraine?
@en
Inhibition of trigeminal neurons by intravenous administration of the serotonin
@nl
type
label
Inhibition of trigeminal neuro ...... herapeutic target in migraine?
@en
Inhibition of trigeminal neurons by intravenous administration of the serotonin
@nl
prefLabel
Inhibition of trigeminal neuro ...... herapeutic target in migraine?
@en
Inhibition of trigeminal neurons by intravenous administration of the serotonin
@nl
P1433
P1476
Inhibition of trigeminal neuro ...... herapeutic target in migraine?
@en
P2093
P304
P356
10.1016/0304-3959(96)03118-1
P407
P577
1996-10-01T00:00:00Z