about
The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein ELCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteinsATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.LCAT deficiency does not impair amyloid metabolism in APP/PS1 miceIntravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus.High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease.ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.Defining the biomechanical and biological threshold of murine mild traumatic brain injury using CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration).High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1.Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice.
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description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Sophie Stukas
@ast
Sophie Stukas
@en
Sophie Stukas
@es
Sophie Stukas
@nl
Sophie Stukas
@sl
type
label
Sophie Stukas
@ast
Sophie Stukas
@en
Sophie Stukas
@es
Sophie Stukas
@nl
Sophie Stukas
@sl
prefLabel
Sophie Stukas
@ast
Sophie Stukas
@en
Sophie Stukas
@es
Sophie Stukas
@nl
Sophie Stukas
@sl
P106
P21
P31
P496
0000-0001-8819-8821
P569
2000-01-01T00:00:00Z