Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.
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Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsBiochemical evidence for the activation of distinct subsets of mitogen-activated protein kinases by voltage and defense-related stimuliProteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine.Application of proteomics in the search for novel proteins associated with the anti-cancer effect of the synthetic cyclin-dependent kinases inhibitor, bohemine.When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry.Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation.A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer CellsStructural basis for the modulation of CDK-dependent/independent activity of cyclin D1.Chemical inhibitors: a tool for plant cell cycle studies.Mechanism targeted discovery of antitumor marine natural products.The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules.Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitorsInhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.The therapeutic potential of targeting the cell cycle.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.A mutation in the tomato DDB1 gene affects cell and chloroplast compartment size and CDT1 transcriptThe experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell linesNovel potent pharmacological cyclin-dependent kinase inhibitors.The impact of multi-targeted cyclin-dependent kinase inhibition in breast cancer cells: clinical implications.Cyclin-dependent kinase modulators and cancer therapy.Why (multi)targeting of cyclin-dependent kinases is a promising therapeutic option for hormone-positive breast cancer and beyond.Discovery of nitroaryl urea derivatives with antiproliferative properties.Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.Roscovitine sensitizes leukemia and lymphoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatment.Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells.Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors.Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones.Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines.2-(1-Adamant-yl)-1-{4-[(2-chloro-9-isopropyl-9H-purin-6-yl)amino-meth-yl]phen-yl}ethanone.Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings.The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture.Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases.Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells.
P2860
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P2860
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@en
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@nl
type
label
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@en
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@nl
prefLabel
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@en
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@nl
P2093
P356
P1476
Cytokinin-derived cyclin-depen ...... moucine and related compounds.
@en
P2093
L Havlícek
P304
P356
10.1021/JM960666X
P407
P577
1997-02-01T00:00:00Z