Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
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Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706A molecular link between the active component of marijuana and Alzheimer's disease pathologyAlzheimer's disease; taking the edge off with cannabinoids?Multi-Target Directed Donepezil-Like Ligands for Alzheimer's DiseaseA Role for the Brain RAS in Alzheimer's and Parkinson's DiseasesAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseStructural insights into ligand interactions at the acetylcholinesterase peripheral anionic site.Freeze-frame inhibitor captures acetylcholinesterase in a unique conformationCrystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assemblyKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationHemodynamic and neuropathological analysis in rats with aluminum trichloride-induced Alzheimer's diseaseDifferential localization of acetylcholinesterase in neuronal and non-neuronal cellsMemoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's diseaseMapping cognitive function.Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors.Insights and ideas garnered from marine metabolites for development of dual-function acetylcholinesterase and amyloid-β aggregation inhibitorsAltered levels of acetylcholinesterase in Alzheimer plasma.Changes in brain MicroRNAs contribute to cholinergic stress reactions.Dual binding site and selective acetylcholinesterase inhibitors derived from integrated pharmacophore models and sequential virtual screening.Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors.Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1.Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase.Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits.The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies.Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.sym-Triazines for directed multitarget modulation of cholinesterases and amyloid-β in Alzheimer's disease.Butyrylcholinesterase attenuates amyloid fibril formation in vitro.Functional recovery of cholinergic basal forebrain neurons under disease conditions: old problems, new solutions?Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease.Correlates of response to acetylcholinesterase inhibitor therapy in Alzheimer's disease.In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studiesRevisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-AmyloidButyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome.A critical review of cholinesterase inhibitors as a treatment modality in Alzheimer's disease.Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.Pyranopyrazolotacrines as nonneurotoxic, Aβ-anti-aggregating and neuroprotective agents for Alzheimer's disease.Emerging links between type 2 diabetes and Alzheimer's diseaseBiochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex.
P2860
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P2860
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Acetylcholinesterase accelerat ...... peripheral site of the enzyme.
@en
Acetylcholinesterase accelerat ...... peripheral site of the enzyme.
@nl
type
label
Acetylcholinesterase accelerat ...... peripheral site of the enzyme.
@en
Acetylcholinesterase accelerat ...... peripheral site of the enzyme.
@nl
prefLabel
Acetylcholinesterase accelerat ...... peripheral site of the enzyme.
@en
Acetylcholinesterase accelerat ...... peripheral site of the enzyme.
@nl
P2093
P1433
P1476
Acetylcholinesterase accelerat ...... peripheral site of the enzyme
@en
P2093
N C Inestrosa
O I Casanueva
P304
P356
10.1016/S0896-6273(00)80108-7
P407
P577
1996-04-01T00:00:00Z