about
Adhesion protein networks reveal functions proximal and distal to cell-matrix contactsE-cadherin-integrin crosstalk in cancer invasion and metastasisIdentification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behaviormDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasionThe membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirementsAn active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL KinaseVisualization of Src activity at different compartments of the plasma membrane by FRET imaging.Two-color photoactivatable probe for selective tracking of proteins and cells.Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancerEpigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.Diversity of matriptase expression level and function in breast cancer.Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.c-Src drives intestinal regeneration and transformation.Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.Translation Microscopy (TRAM) for super-resolution imaging.The SRC-induced mesenchymal state in late-stage colon cancer cells.The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivoA direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.Endosomal trafficking of Src tyrosine kinase.Src and focal adhesion kinase as therapeutic targets in cancer.NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation.Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.The FERM domain: organizing the structure and function of FAK.The calpain system and cancer.Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.Cellular functions of the ADF/cofilin family at a glance.Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Margaret C Frame
@ast
Margaret C Frame
@en
Margaret C Frame
@es
Margaret C Frame
@nl
Margaret C Frame
@sl
type
label
Margaret C Frame
@ast
Margaret C Frame
@en
Margaret C Frame
@es
Margaret C Frame
@nl
Margaret C Frame
@sl
prefLabel
Margaret C Frame
@ast
Margaret C Frame
@en
Margaret C Frame
@es
Margaret C Frame
@nl
Margaret C Frame
@sl
P106
P21
P31
P496
0000-0001-5882-1942
P569
2000-01-01T00:00:00Z