[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.

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The irreversible ERBB1/2/4 inhibitor neratinib interacts with the BCL-2 inhibitor venetoclax to kill mammary cancer cells.The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells.

P2860

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[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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name

[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

@en

[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

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type

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label

[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

@en

[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

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[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

@en

[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

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P1476

[Neratinib + Valproate] exposu ...... es M1 macrophage infiltration.

@en

P2093

Alshad S Lalani

http://www.w3.org/2001/XMLSchema#string

Andrew Poklepovic

http://www.w3.org/2001/XMLSchema#string

Francesca Avogadri-Connors

http://www.w3.org/2001/XMLSchema#string

Jane L Roberts

http://www.w3.org/2001/XMLSchema#string

John Kirkwood

http://www.w3.org/2001/XMLSchema#string

Laurence Booth

http://www.w3.org/2001/XMLSchema#string

Richard E Cutler

http://www.w3.org/2001/XMLSchema#string

Rumeesa Rais

http://www.w3.org/2001/XMLSchema#string

P2860

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling.

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo.

Drugging the HDAC6-HSP90 interplay in malignant cells.

Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells.

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide

HDAC inhibitors enhance the immunotherapy response of melanoma cells.

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo.

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib.

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents.

P304

6062-6074

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scholarly article

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10.18632/ONCOTARGET.23681

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English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Paul Dent

P577

2017-12-26T00:00:00Z

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P698

29464055

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P932

5814195

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[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.

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P2860

P2860

[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.

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P1433

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