DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease.

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DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年學術文章

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DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

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DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

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DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

@en

DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

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DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

@en

DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

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P1476

DEPTOR Suppresses Lipogenesis ...... ry in Alcoholic Liver Disease.

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Alex Sherban

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Allison Nocon

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Amrita Kamat

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Bin Gao

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Bingbing Jiang

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Donghwan Lee

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Farnaz Keyhani-Nejad

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Feng Liu

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Feng Shen

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Hanqing Chen

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S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells

mTOR signaling in growth control and disease

Alcoholic liver disease: pathogenesis and new therapeutic targets.

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

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scholarly article

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10.1002/HEP.29849

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English

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Pal Pacher

Yu Li

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2018-02-19T00:00:00Z

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29457836

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6097912

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