Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system.

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Fingolimod reduces circulating tight-junction protein levels and in vitro peripheral blood mononuclear cells migration in multiple sclerosis patients

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Q58603651-47A69BFC-4DA5-4B19-882C-66AE917B003D

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Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system.

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Fingolimod targets cerebral en ...... in the central nervous system.

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Fingolimod targets cerebral en ...... in the central nervous system.

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type

Item

label

Fingolimod targets cerebral en ...... in the central nervous system.

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Fingolimod targets cerebral en ...... in the central nervous system.

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Fingolimod targets cerebral en ...... in the central nervous system.

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Fingolimod targets cerebral en ...... in the central nervous system.

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P1476

Fingolimod targets cerebral en ...... in the central nervous system.

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Dongyan Shi

http://www.w3.org/2001/XMLSchema#string

Fengjiao Wu

http://www.w3.org/2001/XMLSchema#string

Hong Zhou

http://www.w3.org/2001/XMLSchema#string

Kelei Cao

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Keqi Zhang

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Lixin Liu

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Qiang You

http://www.w3.org/2001/XMLSchema#string

Shuang Wen

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Xingxing Zhu

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Yawei Zhao

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P2860

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress

Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response

Molecular cloning and functional characterization of murine sphingosine kinase

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

Neutrophils in the activation and regulation of innate and adaptive immunity

FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.

Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial.

Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins.

Trafficking of immune cells in the central nervous system

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107-118

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scholarly article

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10.1002/JLB.3A0717-287R

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103

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2017-12-06T00:00:00Z

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29345065

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Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system.

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P2860

P2860

Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system.

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P1476

P2093

P2860

P304

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P356

P433

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P698

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P1433

P1476

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P2860

P304

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P356

P433

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